Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/101739| Title: | Impact of N-heteroaromatic N-termini in Cu(ii) ATCUN metallopeptides on their biorelevant redox activity |
| Author(s): | Barrera, Jannis Haeri, Haleh H. Heinrich, Julian Stein, Matthias Hinderberger, Dariush  Kulak, Nora |
| Issue Date: | 2023 |
| Type: | Article |
| Language: | English |
| Abstract: | Cu(II) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation of N-heteroaromatics reinstates ROS production which leads to efficient DNA cleavage. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/103686 http://dx.doi.org/10.25673/101739 |
| Open Access: |  Open access publication |
| License: |  (CC BY 3.0) Creative Commons Attribution 3.0 Unported |
| Journal Title: | Dalton transactions |
| Publisher: | Soc. |
| Publisher Place: | London |
| Volume: | 52 |
| Issue: | 11 |
| Original Publication: | 10.1039/d2dt02044k |
| Page Start: | 3279 |
| Page End: | 3286 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| d2dt02044k.pdf | 2.8 MB | Adobe PDF |  View/Open |