Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/110697
Title: | Rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis : a possible interface? |
Author(s): | Schulz, Susanne![]() Zimmer, Pauline Pütz, Natalie Alexandra ![]() Jurianz, Elisa ![]() Schaller, Hans-Günter Reichert, Stefan ![]() |
Issue Date: | 2020 |
Type: | Article |
Language: | English |
Abstract: | Background: Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), CTLA4 genes (rs3087243) and its impact on RA and PD. Materials and methods: In the study 111 RA patients and 256 systemically healthy controls were involved. A subdivision of patients and controls was carried out according the severity of periodontitis (no/level 1 PD vs. level 2 PD). Results: I. Evaluating the genetic impact on the occurrence of RA the T allele of rs2476601 (PTPN22) (bivariate: p < 0.001; multivariate: p = 0.018) and T allele of rs2240340 (PADI4) (bivariate: p = 0.006; multivariate: p = 0.070) were associated with an increased vulnerability to RA. II. Investigating the genetic influence on level 2 PD the T allele of rs2476601 (PTPN22) was shown to be associated with a higher susceptibility to PD within the RA group (bivariate: p = 0.043; multivariate: p = 0.024). III. The T allele of rs2476601 (PTPN22) was proven to be a significant marker of RA and level 2 PD comorbidity (bivariate: p < 0.001; multivariate: p = 0.028). Conclusions: These results support the thesis that genetic variations may represent a possible link between PD and RA. The study increases knowledge about disease-specific and cross-disease genetic pattern. |
URI: | https://opendata.uni-halle.de//handle/1981185920/112652 http://dx.doi.org/10.25673/110697 |
Open Access: | ![]() |
License: | ![]() |
Journal Title: | Journal of translational medicine |
Publisher: | BioMed Central |
Publisher Place: | London |
Volume: | 18 |
Issue: | 389 |
Original Publication: | 10.1186/s12967-020-02548-w |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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s12967-020-02548-w.pdf | 1.11 MB | Adobe PDF | ![]() View/Open |