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http://dx.doi.org/10.25673/111382| Title: | Plasma β-synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy |
| Author(s): | Abu Rumeileh, Samir Barba, Lorenzo Bache, Matthias Halbgebauer, Steffen Oeckl, Patrick Steinacker, Petra Güttler, Antje Kessler-Silacci, Jacqueline Illert, Jörg Strauss, Christian Vordermark, Dirk Otto, Markus |
| Issue Date: | 2023 |
| Type: | Article |
| Language: | English |
| Abstract: | We analyzed the longitudinal concentrations and prognostic roles of plasma β-synuclein (β-syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β-syn, NfL and NfH increased after surgery, whereas GFAP decreased at long-term follow-up. β-syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/113336 http://dx.doi.org/10.25673/111382 |
| Open Access: |  Open access publication |
| License: |  (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0 |
| Journal Title: | Annals of Clinical and Translational Neurology |
| Publisher: | Wiley |
| Publisher Place: | Chichester [u.a.] |
| Volume: | 10 |
| Issue: | 10 |
| Original Publication: | 10.1002/acn3.51878 |
| Page Start: | 1924 |
| Page End: | 1930 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Ann Clin Transl Neurol - 2023 - Abu‐Rumeileh - Plasma ‐synuclein GFAP and neurofilaments in patients with malignant.pdf | 609.76 kB | Adobe PDF |  View/Open |