Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/119087
Title: Perspectives on the role of “-Omics” in predicting response to immunotherapy
Author(s): Giacomo, Anna Maria
Subudhi, Sumit
Vos, Wim
Andreatta, Massimo
Carmona, Santiago
McTavish, Will
Seliger, BarbaraLook up in the Integrated Authority File of the German National Library
Ibrahim, Ramy
Lahn, MichaelLook up in the Integrated Authority File of the German National Library
Smith, Michael
Eggermont, AlexanderLook up in the Integrated Authority File of the German National Library
Fox, Bernard A.
Maio, Michele
Issue Date: 2025
Type: Article
Language: English
Abstract: The annual Immuno-Oncology “Think Tank” held in October 2023 in Siena reviewed the rapidly evolving systems-biological approaches which are now providing a deeper understanding of tumor and tumor microenvironment heterogeneity. Based on this understanding opportunities for novel therapies may be identified to overcome resistance to immunotherapy. There is increasing evidence that malignant disease processes are not limited to purely intracellular or genetic events but constitute a dynamic interaction between the host and disease. Tumor responses are influenced by many host tissue determinants across different cellular compartments, which can now be investigated by high-throughput molecular profiling technologies, often labelled with a suffix “-omics”. “Omics” together with ever increasing computational power, fast developments in machine learning, and high-resolution detection tools offer an unrivalled opportunity to connect high-dimensional data and create a holistic view of disease processes in cancer. This review describes advances in several state-of-the-art “-omics” approaches with perspectives on how these can be applied to the clinical development of new immunotherapeutic strategies and ultimately adopted in clinical practice.
URI: https://opendata.uni-halle.de//handle/1981185920/121043
http://dx.doi.org/10.25673/119087
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: European journal of cancer
Publisher: Elsevier
Publisher Place: Amsterdam [u.a.]
Volume: 220
Original Publication: 10.1016/j.ejca.2025.115393
Page Start: 1
Page End: 6
Appears in Collections:Open Access Publikationen der MLU

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