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http://dx.doi.org/10.25673/37468
Titel: | Androgen-regulated microRNAs (AndroMiRs) as novel players in adipogenesis |
Autor(en): | Jansen, Julia Greither, Thomas ![]() Behre, Hermann M. ![]() |
Erscheinungsdatum: | 2019 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | The development, homeostasis, or increase of the adipose tissue is driven by the induction of the adipogenic differentiation (adipogenesis) of undifferentiated mesenchymal stem cells (MSCs). Adipogenesis can be inhibited by androgen stimulation of these MSCs resulting in the transcription initiation or repression of androgen receptor (AR) regulated genes. AR not only regulates the transcription of protein-coding genes but also the transcription of several non-coding microRNAs involved in the posttranscriptional gene regulation (herein designated as AndroMiRs). As microRNAs are largely involved in differentiation processes such as adipogenesis, the involvement of AndroMiRs in the androgen-mediated inhibition of adipogenesis is likely, however, not yet intensively studied. In this review, existing knowledge about adipogenesis-related microRNAs and AndroMiRs is summarized, and putative cross-links are drawn, which are still prone to experimental validation. |
URI: | https://opendata.uni-halle.de//handle/1981185920/37711 http://dx.doi.org/10.25673/37468 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Sponsor/Geldgeber: | Publikationsfond MLU |
Journal Titel: | International journal of molecular sciences |
Verlag: | MDPI |
Verlagsort: | Basel |
Band: | 20 |
Heft: | 22 |
Originalveröffentlichung: | 10.3390/ijms20225767 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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ijms-20-05767.pdf | 767.67 kB | Adobe PDF | ![]() Öffnen/Anzeigen |