Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.25673/38264| Titel: | What turns CREB on? And off? And why does it matter? |
| Autor(en): | Steven, André Friedrich, Michael Jank, Paul Heimer, Nadine Budczies, Jan  Denkert, Carsten Seliger, Barbara |
| Erscheinungsdatum: | 2020 |
| Art: | Artikel |
| Sprache: | Englisch |
| Zusammenfassung: | Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/38507 http://dx.doi.org/10.25673/38264 |
| Open-Access: |  Open-Access-Publikation |
| Nutzungslizenz: |  (CC BY 4.0) Creative Commons Namensnennung 4.0 International |
| Sponsor/Geldgeber: | Publikationsfond MLU |
| Journal Titel: | Cellular and molecular life sciences |
| Verlag: | Springer International Publishing AG |
| Verlagsort: | Cham (ZG) |
| Band: | 77 |
| Heft: | 20 |
| Originalveröffentlichung: | 10.1007/s00018-020-03525-8 |
| Seitenanfang: | 4049 |
| Seitenende: | 4067 |
| Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| Steven2020_Article_WhatTurnsCREBOnAndOffAndWhyDoe.pdf | 2.14 MB | Adobe PDF |  Öffnen/Anzeigen |