Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/38355| Title: | Synthesis and cytotoxic evaluation of malachite green derived oleanolic and ursolic acid piperazineamides |
| Author(s): | Friedrich, Sander Serbian, Immo  Hoenke, Sophie Wolfram, Ratna Kancana Csuk, René |
| Issue Date: | 2020 |
| Type: | Article |
| Language: | English |
| Abstract: | The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with meta or para substituted carboxylated malachite green analogs gave conjugates 10, 11, 15, and 16 that were cytotoxic for several human tumor cell lines. Especially, an oleanolic acid-derived compound 10 was cytotoxic for MCF-7 human breast carcinoma cells (EC50 = 0.7 μM). These derivatives represent first examples of triterpenoic acid derivatives holding a cationic scaffold derived from malachite green. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/38598 http://dx.doi.org/10.25673/38355 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Sponsor/Funder: | Publikationsfond MLU |
| Journal Title: | Medicinal chemistry research |
| Publisher: | Birkhäuser Boston |
| Publisher Place: | Cambridge, Mass. [u.a.] |
| Volume: | 29 |
| Issue: | 5 |
| Original Publication: | 10.1007/s00044-020-02536-1 |
| Page Start: | 926 |
| Page End: | 933 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Friedrich2020_Article_SynthesisAndCytotoxicEvaluatio.pdf | 976.35 kB | Adobe PDF |  View/Open |