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http://dx.doi.org/10.25673/38424
Titel: | 1H, 13C, and 15N Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein |
Autor(en): | Lang, Andras Kumar, Amit Jirschitzka, Jan Bordusa, Frank Ohlenschläger, Oliver Wiedemann, Christoph |
Erscheinungsdatum: | 2020 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | The brain and acute leukemia cytoplasmic (BAALC; UniProt entry Q8WXS3) is a 180-residue-long human protein having six known isoforms. BAALC is expressed in either hematopoietic or neuroectodermal cells and its specific function is still to be revealed. However, as a presumably membrane-anchored protein at the cytoplasmic side it is speculated that BAALC exerts its function at the postsynaptic densities of certain neurons and might play a role in developing cytogenetically normal acute myeloid leukemia (CN-AML) when it is highly overexpressed by myeloid or lymphoid progenitor cells. In order to better understand the physiological role of BAALC and to provide the basis for a further molecular characterization of BAALC, we report here the 1H, 13C, and 15N resonance assignments for the backbone nuclei of its longest hematopoietic isoform (isoform 1). In addition, we present a 1HN and 15NH chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the 1H and 15N chemical shifts. |
URI: | https://opendata.uni-halle.de//handle/1981185920/38667 http://dx.doi.org/10.25673/38424 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Sponsor/Geldgeber: | Publikationsfonds MLU |
Journal Titel: | Biomolecular NMR Assignments |
Verlag: | Springer |
Verlagsort: | Dordrecht |
Band: | 14 |
Originalveröffentlichung: | 10.1007/s12104-020-09938-7 |
Seitenanfang: | 163 |
Seitenende: | 168 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Lang2020_Article_1H13CAnd15NBackboneAssignments.pdf | 1.96 MB | Adobe PDF | ![]() Öffnen/Anzeigen |