Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/54782
Title: | n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli |
Author(s): | Serbian, Immo Prell, Erik Fischer, Claudia Deigner, Hans-Peter Csuk, René |
Issue Date: | 2021 |
Type: | Article |
Language: | English |
Abstract: | A convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n-propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside (8) was an excellent competitive inhibitor for the β-galactosidase from E. coli holding a Ki of 0.50 μM. |
URI: | https://opendata.uni-halle.de//handle/1981185920/56734 http://dx.doi.org/10.25673/54782 |
Open Access: | ![]() |
License: | ![]() |
Sponsor/Funder: | Publikationsfonds MLU |
Journal Title: | Medicinal Chemistry Research |
Publisher: | Birkhäuser Boston |
Publisher Place: | Cambridge, Mass. [u.a.] |
Volume: | 30 |
Original Publication: | 10.1007/s00044-021-02715-8 |
Page Start: | 1099 |
Page End: | 1107 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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Serbian2021_Article_N-Propyl6-amiNo-26-DiDeoxy-22-.pdf | 851.42 kB | Adobe PDF | ![]() View/Open |