Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/54782| Title: | n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli |
| Author(s): | Serbian, Immo Prell, Erik Fischer, Claudia Deigner, Hans-Peter Csuk, René |
| Issue Date: | 2021 |
| Type: | Article |
| Language: | English |
| Abstract: | A convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n-propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside (8) was an excellent competitive inhibitor for the β-galactosidase from E. coli holding a Ki of 0.50 μM. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/56734 http://dx.doi.org/10.25673/54782 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Sponsor/Funder: | Publikationsfonds MLU |
| Journal Title: | Medicinal Chemistry Research |
| Publisher: | Birkhäuser Boston |
| Publisher Place: | Cambridge, Mass. [u.a.] |
| Volume: | 30 |
| Original Publication: | 10.1007/s00044-021-02715-8 |
| Page Start: | 1099 |
| Page End: | 1107 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Serbian2021_Article_N-Propyl6-amiNo-26-DiDeoxy-22-.pdf | 851.42 kB | Adobe PDF |  View/Open |