Phase behavior of solvent-rich compositions of the polymer/drug system poly(butylene succinate) and N,N-diethyl-3-methylbenzamide (DEET)

Abstract

Poly(butylene succinate) (PBS) is used to produce micro-/nanoporous biodegradable scaffolds, suitable for the release of the mosquito repellent N,N-diethyl-3-methylbenzamide (DEET), based on thermally induced phase separation. For solvent-rich compositions up to 30 m% PBS, it was found that PBS dissolves in DEET at elevated temperatures. During cooling, spherulitic crystallization of PBS occurs, with the crystallization temperature decreasing with the content of DEET and the cooling rate, as determined by cloud-point measurements, differential scanning calorimetry, and polarized-light optical microscopy. Scaffold morphologies of quenched solutions were analyzed by scanning electron microscopy as a function of the polymer concentration and the quenching temperature. These two parameters control the nucleus density/spherulite size, the degree of intermeshing of spherulites, and the intra- and interspherulitic pore size, with the latter typically being of the order of magnitude of few micrometers.