Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/86328
Title: Curcumin : useful add-on for rheumatic diseases?
Author(s): Tomaras, Stylianos
Keyßer, Gernot
Feist, Eugen
Issue Date: 2022
Type: Article
Language: English
Abstract: Plant-derived nutraceuticals are proposed as new key instruments to represent a profound “back to basics” shift in medical treatment. Data accumulated over the past ten years suggest that curcumin, the major active compound of the turmeric plant, has anti-inflammatory properties. It has yet to be determined whether the anti-inflammatory profile of curcumin is potent enough to justify the application of this substance as a nutritional supplement for patients with rheumatic diseases. To address this question, the most relevant in vitro studies that investigate the mechanism of action of curcumin were reviewed in this article. In addition, a total of 18 animal and human trials were evaluated. The pleiotropic, anti-inflammatory and immunomodulatory effects of curcumin were observed in animal studies. In addition, human trials demonstrated promising findings. In these studies, curcumin was able to reduce the expression of proinflammatory cytokines, lower the level of the C-reactive protein and improve clinical parameters. A limiting factor of the application of curcumin is the inconsistent bioavailability of the substance. Therefore, new formulations have been developed to improve the pharmacodynamic profile of curcumin. The future acceptance of the substance is dependent on new controlled clinical trials with a standardised formulation of curcumin administered as well as standard of care.
URI: https://opendata.uni-halle.de//handle/1981185920/88281
http://dx.doi.org/10.25673/86328
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Journal of Clinical Medicine
Publisher: MDPI
Publisher Place: Basel
Volume: 11
Issue: 10
Original Publication: 10.3390/jcm11102908
Appears in Collections:Open Access Publikationen der MLU

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