https://opendata.uni-halle.de//handle/1981185920/35794 2026-04-14T21:34:43Z 2026-04-14T21:34:43Z Khomeriki, Ramaz Dörr, Kathrin Berakdar, Jamal https://opendata.uni-halle.de//handle/1981185920/124933 2026-04-14T20:01:02Z 2026-01-01T00:00:00Z

Title: Conductive domain walls in ferroelectrics as tunable coherent and chiral THz radiation source Author(s): Khomeriki, Ramaz; Dörr, Kathrin; Berakdar, Jamal Abstract: THz emission associated with currents in conductive domain walls in BiFeO3 following infrared radiation is theoretically investigated. This experimentally observed phenomenon is explained by the domain wall stripes acting as metallic resonators, with the oscillating charge accumulation being at the domain wall edges. The charge oscillation frequency is related to the plasma frequency inside the domain wall. The value of plasma frequency determines both the frequency and the amplitude of the emission emanating from the BiFeO3 sample. We show that for certain geometries of the domain wall structure and for specific polarization of the incident pulse, the THz emission embodies a non-vanishing chirality.

2026-01-01T00:00:00Z Sachan, Shubhra Bhatia, Twinkle Baumann, Monika Weber, Manuel Gordijenko, Ilja Voigt, Bruno Ott, Maria Balbach, Jochen https://opendata.uni-halle.de//handle/1981185920/124932 2026-04-14T20:01:08Z 2026-01-01T00:00:00Z

Title: The intrinsically disordered region of the human parathyroid hormone controls functional amyloid properties Author(s): Sachan, Shubhra; Bhatia, Twinkle; Baumann, Monika; Weber, Manuel; Gordijenko, Ilja; Voigt, Bruno; Ott, Maria; Balbach, Jochen Abstract: Human parathyroid hormone (PTH), which regulates the calcium and phosphate levels in blood, forms functional amyloid fibrils, which are believed to be the storage form during secretion from parathyroid glands. We investigated by various biophysical approaches the role of the intrinsically disordered C-terminal section 35 to 84 of the peptide hormone, which is conserved in mammals but not required for activation of the target G protein–coupled PTH receptors. The flanking intrinsically disordered region (IDR) of PTH, which is not part of the cross-β fibrillar core structure, impairs the lateral filament order and reduces the thermodynamic stability to an extent that monomer release from the fibrils reaches a physiological level. Concentration-dependent fibrillation kinetics revealed that the IDR increases the critical fibrillation and oligomer concentration and screens secondary nucleation. We propose that the IDRs of PTH shape the generic property of the hormone to form amyloid fibrils toward the physiological requirement of monomer release after cellular storage.

2026-01-01T00:00:00Z Vujasinovic, Miroslav Demir, Ihsan Ekin Marchegiani, Giovanni Hegyi, Péter Archibugi, Livia Valente, Roberto Capurso, Gabriele Rosendahl, Jonas Regel, Ivonne https://opendata.uni-halle.de//handle/1981185920/124931 2026-04-14T20:01:01Z 2026-01-01T00:00:00Z

Title: International multidisciplinary consensus report on definitions, diagnostic criteria, and management of fatty pancreas : a joint statement endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG Author(s): Vujasinovic, Miroslav; Demir, Ihsan Ekin; Marchegiani, Giovanni; Hegyi, Péter; Archibugi, Livia; Valente, Roberto; Capurso, Gabriele; Rosendahl, Jonas; Regel, Ivonne Abstract: This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt “fatty pancreas” as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reporting and clinical communication. Another major contribution of the report is the consensus on diagnostic imaging findings, which was based on radiological and endoscopic modalities. The proposed criteria aim to enhance consistency in clinical assessment and support the development of standardized research protocols. In addition to establishing terminology and diagnostic frameworks, the report also synthesizes current knowledge across a wide range of relevant domains. These include the etiology and epidemiology of fatty pancreas, as well as its associations with alcohol consumption, smoking, acute and chronic pancreatitis, pancreatic exocrine insufficiency, type 2 diabetes mellitus, and surgical outcomes. The potential links between fatty pancreas and neoplastic conditions such as intraductal papillary mucinous neoplasms and pancreatic cancer are also addressed, alongside the current understanding of its metabolic implications (beta-cell function and glucose homeostasis) and treatment strategies. Throughout the consensus process, a consistent theme emerged: the limited availability of high-quality, prospective clinical data. Therefore, many of the recommendations in this report are based on expert consensus rather than strong empirical evidence. As such, the statements require rigorous prospective validation before they can be adopted into routine clinical practice. This underscores a critical need for further research, particularly studies aimed at clarifying causal relationships, validating diagnostic tools, and determining the clinical relevance of fatty pancreas across diverse patient populations. This report serves as both a summary of our current understanding and a roadmap for future investigations, aiming to close existing knowledge gaps and guide evidence-based clinical practice in this emerging field.

2026-01-01T00:00:00Z Håkansson, Bo E. V. Jansson, Karl-Johan Fredén Verrecchia, Luca Tawfique, Zheer Fröhlich, Laura Dlugaiczyk, Julia Rahne, Torsten Eeg-Olofsson, Måns Håkansson, Emil Reinfeldt, Sabine https://opendata.uni-halle.de//handle/1981185920/124930 2026-04-14T20:00:56Z 2026-01-01T00:00:00Z

Title: Ocular VEMP using bone conduction stimuli at the forehead : a pilot study comparing B250, minishaker and tendon hammer with vibrometry validation Author(s): Håkansson, Bo E. V.; Jansson, Karl-Johan Fredén; Verrecchia, Luca; Tawfique, Zheer; Fröhlich, Laura; Dlugaiczyk, Julia; Rahne, Torsten; Eeg-Olofsson, Måns; Håkansson, Emil; Reinfeldt, Sabine Abstract: Background: Bone-conduction stimuli in oVEMP testing offer lower stimulus levels and independence of conductive hearing loss but lack a clinically suitable transducer for excitation. A new bone-conduction transducer (B250) has been developed which is easy to attach and can be directly connected to test stations. Objective: To compare, in a pilot investigation B250, Minishaker and Tendon hammer excitation, used for oVEMP and mastoid vibration measurements. Methods: oVEMPs in three subjects were measured using transducers driven by a 250 Hz condensation single sinus cycle and with a Tendon hammer, all applied at forehead Fz/AFz. Corresponding mastoid velocity was measured using a laser Doppler vibrometer (LDV). Results: B250 and Minishaker often produced dual oVEMP peaks with an early n1 (mean latency: 8.8 ms) and a late n2 response (B250: 12.4/Minishaker: 13.3 ms), and with the Tendon hammer response in between. This finding was supported by a reinvestigation of a previous study (n=15). LDV velocity shows several positive peaks for B250 and one positive peak for the Minishaker. The acceleration response has two peaks 4 ms apart for both transducers, which seem to relate to the early and late oVEMP latencies. Conclusion: B250 may serve as a potential alternative, pending validation in larger samples, to the Minishaker at the forehead, but with care to polarity choice and latency interpretation.

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