https://opendata.uni-halle.de//handle/1981185920/6693 2026-10-14T01:21:06Z https://opendata.uni-halle.de//handle/1981185920/127678 Title: On topological and geodesic complexities of manifolds Author(s): Mescher, Stephan; Rademacher, Hans-Bert Abstract: This habilitation thesis consists of six original research articles, published between 2019 and 2023, dealing with the topological and geometric complexities of smooth manifolds. Its first line of research establishes new cohomological lower bounds for topological complexity, including links to domination of manifolds by products and computations of topological complexities for certain symplectic manifolds. The second line of research considers geodesic complexities of homogeneous Riemannian manifolds, introducing a notion of fibered decompositions of cut loci and computing geodesic complexities of complex projective spaces, lens spaces and tori. In the third line of research, spherical complexities are introduced as integer-valued invariants that can be used to estimate numbers of critical orbits of functionals on loop and sphere spaces invariant under group actions. From this approach new existence results for closed geodesics in Finsler manifolds are derived. 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/127661 Title: The SARS-CoV-2 N protein : development of a mass spectrometric assay for SARS-CoV-2 detection and structural characterization of N protein - G3BP1 interactions Author(s): Kollhoff, Lydia Abstract: A rapid and highly specific assay was developed to detect the SARS-CoV-2 N protein with MALDI-TOF-MS. The assay is suitable for high-throughput screening as MALDI-TOF mass spectrometers are available in many clinics. As the assay is based on a direct detection of peptides derived from the N protein, the virus load can be accurately quantified. Also, the assay can discriminate different viral strains as was shown by distinguishing the delta variant from other variants in swab samples. The N protein was structurally characterized with respect to its interactions with human G3BP1, one of the key factors in stress granule (SG) formation. The N protein was shown to impair SG formation by its interaction with G3BP1. While the influence of N protein on SG formation has been confirmed in vivo and in vitro, the molecular details are still elusive. Structural characterization with XL-MS and native PAGE served as basis for AlphaFold 3-based modeling of the protein - protein interactions. 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/127658 Title: A context-sensitive examination of critical consciousness development in youth with diverse societal positioning : the role of cultural identity and ethnic-racial socialization Author(s): Kehl, Judith Abstract: This research examines how youth develop critical consciousness (CC) of societal inequities and racism in Germany and Northern Ireland. Integrating CC theory with developmental and social psychology, I examine links among CC components and how cultural identity and school and family ethnic-racial socialization predict CC, considering societal positioning. Drawing on four quantitative studies with adolescents, teachers, and emerging adults, findings show that critical reflection and motivation were often linked to action, though this link did not persist over time. Cultural identity was uniquely related to CC, while school and family socialization showed differential associations, with practices addressing inequities linked to higher CC. Associations were largely consistent, though some varied by youth’s societal positioning. Findings highlight contextually grounded CC approaches and support for families and educators in fostering critical dialogue and inclusive identity narratives. 2025-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/127657 Title: Die thylakoidäre Tat-Translokase : auf dem Weg von Struktur zur Funktion Author(s): Kistner, Nicolas Abstract: Die Arbeit untersucht den Proteintransport über die Thylakoidmembran durch die Twin-Arginin-Translokase (Tat). Mithilfe von In-silico-Analysen wurde ein trichterförmiger TatBC-Komplex mit je drei Untereinheiten modelliert, der Substrate auf stromaler Seite binden kann. Die grundlegende Struktur wurde für thylakoidäre, mitochondriale sowie prokaryotische Tat-Systeme gezeigt. TatA zeigte dabei vermutlich eine dynamische Rolle im Transportprozess. Ergänzende Experimente deuteten darauf hin, dass TatA nach aktiver Beteiligung aus der Membran gelöst und zyklisch wiederverwendet werden kann. Insgesamt liefert die Arbeit ein neues strukturelles und funktionelles Modell des Tat-Transports. 2026-01-01T00:00:00Z