https://opendata.uni-halle.de//handle/1981185920/35794 Fri, 17 Jul 2026 05:40:58 GMT 2026-07-17T05:40:58Z https://opendata.uni-halle.de//handle/1981185920/126067 Title: Diverging population structure and behaviour of two butterfly species with contrasting ecological performance in an Ethiopian church forest Author(s): Habel, Jan Christian; Schmitt, Thomas; Stockl, Barbara; Hailay, Gebreegziabher; Bezabih, Azmeraw Alemkere; Ulrich, Werner; Teucher, Mike; Eberle, Jonas Abstract: Ecology and habitat demand of species determine their population structure and dynamics as well as their behaviour and responses to habitat changes. Species specialised to forest ecosystems are assumed to behave differently in these ecosystems than generalist species, which also occur in open ecosystems. For assessing how species with different ecological performance thrive in a small remnant forest, we selected two butterfly species with different degrees of habitat specialisation. We conducted a mark-release-recapture study in a church forest in northern Ethiopia to investigate the population ecology of these two species. As model species we selected the forest species Junonia terea and the habitat generalist Phalantha phalantha. We found for both species that one generation was fading out in the second half of the dry season but was substituted by the onset of eclosion of a follow-up generation. This population dynamic was also supported by population size dynamics, capture probability and survival probability. Life spans were comparatively short for both species, except for some few individuals. Dispersal behaviour of P. phalantha was very low, while J. terea was more dispersive, a common feature in forest butterflies. P. phalantha preferred habitats characterised by ground cover, litter, flowering plants and little shade. It thus preferred light spots inside the forest confirming the typical ecological niche of a generalist species being more common in open habitats than in forests. No habitat preferences were obtained for the euryoecious forest species J. terea, which thus occurs virtually anywhere in wooded habitats. Implications for insect conservation Our study clearly shows that the ecological performance of these two species had a significant influence on habitat selection, population dynamics, and behaviour. Our findings underline the high conservation value of still intact forest ecosystems to hold typical and highly specialized forest species. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126067 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/126066 Title: Development of a digitalised complex intervention to promote activity of older people in rural areas : study protocol of a feasibility study Author(s): Beutner, Katrin; Lamprecht, Juliane; Roggendorf, Sigrid; Aßmann, Paula; Hübner, Gundula; Steckelberg, Anke; Schmidt, Heike Birgit Abstract: Background Age-related mobility limitations are associated with reduced activity and loss of participation, which can result in loneliness and depression. Physical activity programmes can help maintain the functional status and quality of life of older individuals, but they are rarely available and often difficult to reach, especially in rural areas. Digital-assisted programmes have the potential, independent of place and time, to activate and promote physical function and social participation in older people. Therefore, this study aims (1) to develop a complex intervention comprising digital elements to promote physical activity, quality of life and participation in older people with impending or existing functional limitations and (2) to test the feasibility, acceptability, and potential benefits of the developed intervention. Methods The development and piloting of the intervention follow the UK Medical Research Council framework for complex interventions. The intervention will be developed through participatory co-production, integrating the perspectives of all potentially relevant user groups, including older people, physiotherapists, general practitioners, and day care facilities in the participating regions. Co-production is guided by the principles of early stakeholder involvement, iterative refinement, usability-oriented development, and shared decision-making regarding intervention content and delivery. The developed intervention will be examined using a consecutive control intervention group design with 60 older people (aged ≥ 65 years) in rural areas of Saxony-Anhalt who have existing or imminent mobility restrictions and have a medical prescription for physiotherapy. The primary feasibility outcomes will be recruitment rate, completion rate, acceptability, and compliance with the study procedures and the intervention assessed by protocols, utilisation data, questionnaires, and interviews at 20-weeks follow-up. Quantitative and qualitative findings will be integrated during interpretation using a convergent mixed-methods approach. Secondary patient-related outcomes will be physical function, physical activity, self-care, quality of life, and participation measured at baseline and after 12 weeks. Discussion The study aims to evaluate the feasibility of a new intervention designed to promote physical activity and participation among older people living in rural areas. The findings will inform intervention refinement and the design of a future definitive randomised controlled trial. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126066 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/126065 Title: Bridging atomistic and mesoscale lithium transport via machine-learned force fields and Markov state models Author(s): Qaisrani, Muhammad Nawaz; Kirsch, Christoph; Flötotto, Aaron; Hänseroth, Jonas; Oumard, Jules Jean Max; Sebastiani, Daniel; Dreßler, Christian Abstract: Lithium diffusion in silicon battery anodes is governed by thermally activated jumps between (meta)stable sites separated by significant energy barriers, making such events rare on ab initio molecular dynamics (AIMD) time scales. To overcome this limitation, we establish a multiscale workflow that links AIMD, machine-learned force fields (MLFFs), and Markov state models (MSMs) to bridge atomistic mechanisms to mesoscale diffusion. Focusing on crystalline Li–Si phases, our MLFFs trained on AIMD data, achieve near-DFT accuracy while enabling large-scale molecular dynamics simulations extending to tens of nanoseconds. From these trajectories, we extract converged lithium-jump statistics to construct MSMs that quantitatively reproduce diffusivities with uncertainties an order of magnitude smaller than those obtained from 100 ps AIMD simulations. Demonstrated here for crystalline LixSiy phases, the AIMD → MLFF → MSM workflow provides a transferable route for quantitative transport modeling in amorphous structures, defect-mediated diffusion, and alternative solid-state anodes. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126065 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/126064 Title: Native mass spectrometry reveals binding modes of the tumor suppressor protein p53 to different DNA response elements Author(s): Siefke, Erik; Arlt, Christian; Sinz, Andrea Abstract: We used native mass spectrometry (MS) to investigate how the architecture of the p21 DNA response element (DNA-RE) controls the binding mode of the tumor suppressor protein p53. We analyzed tetrameric full-length wild-type p53 and compared its DNA binding behavior with a dimeric variant, p53L344A. In total, 37 DNA constructs derived from p21 DNA-RE were examined via native MS, including full-site sequences, isolated half-sites, variants differing in length and composition, and random DNA sequences. The aim was to define the minimal DNA requirements for p53 binding using native MS as a robust platform for comparative analysis of p53:DNA assemblies. Our results show that flanking regions of the full 20-bp DNA-RE have no influence on the initial formation of p53:DNA complexes. However, the complete 20-bp site is required for both p53wild-type and p53L344A to bind to DNA as tetramers. Binding of a single dimer to an isolated half-site is insufficient for generating the stable tetrameric p53:DNA complex. These findings indicate that dimer-dimer interactions are crucial for stabilizing the tetrameric p53:DNA complex. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126064 2026-01-01T00:00:00Z