https://opendata.uni-halle.de//handle/1981185920/6693 Thu, 13 Aug 2026 06:39:54 GMT 2026-08-13T06:39:54Z https://opendata.uni-halle.de//handle/1981185920/126451 Title: Deciphering the spatial immune cell organization in the tumor microenvironment and its impact on desease progression Author(s): Bauer, Marcus Abstract: The tumor microenvironment (TME) plays a central role in cancer progression and patient outcome but remains insufficiently characterized in hematological malignancies and underrepresented populations. This work combines spatial immune profiling of healthy and neoplastic bone marrow biopsies with the analysis of more than 1,600 breast cancer samples from 10 sub-Saharan African countries using conventional and multiplex immunohistochemistry. The findings demonstrate that immune cell composition and spatial organization change during malignant transformation, are associated with genetic alterations, disease progression, and prognosis, and differ between populations with distinct genetic backgrounds and infectious exposures. These results underscore the value of spatially resolved TME analysis for understanding tumor biology and support the integration of multiplex imaging into precision pathology and personalized cancer care. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126451 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/126434 Title: Thermodynamics of fluorophilicity, lipophilicity, and hydrophilicity of fluorescent molecules Author(s): Abu Bakar, Muhammad Abstract: Fluorinated derivatives of proflavine, aniline yellow, 1-aminopyrene, and o-aminoazotoluol were synthesized and characterized by ESI-ToF mass spectrometry and 1H/19F NMR spectroscopy, confirming successful fluorination. Their photophysical properties were evaluated using UV-Vis absorption and fluorescence spectroscopy. Fluorinated proflavine and aniline yellow derivatives showed enhanced fluorescence with red-shifted absorption and emission, while proflavine derivatives exhibited the greatest enhancement due to their planar acridine core, extended π-conjugation, and symmetrical incorporation of two perfluoroalkyl chains. Fluorinated 1-aminopyrene and o-aminoazotoluol derivatives displayed chain-length-dependent blue shifts while maintaining improved optical properties. Partition studies demonstrated increased fluorophilicity with longer perfluoroalkyl chains, highlighting the potential of these fluorinated dyes for bioimaging, fluorescence labeling, sensing, and fluorinated-phase applications. Wed, 01 Jan 2025 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126434 2025-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/126433 Title: Development and evaluation of a multimodal supportive intervention for promoting the physical function of older patients with cancer Author(s): Levallet, Eni Abstract: Older patients with cancer are heterogeneous in their physical function (PF), cognitive function, and comorbidities. Despite tailored oncologic therapies, PF may decline. Therefore, this study developed and pilot-tested a multimodal intervention combining individualized physical activity and dietary recommendations to promote PF in older patients undergoing outpatient radiotherapy. The intervention was delivered either digitally or in paper format. Participants received an individualized, home-based program based on comprehensive assessments and personal goals. Feasibility, acceptance, adherence, and potential benefit were evaluated after 12 weeks and at follow-up. In the sample (n=24; 70±7 years), both formats were well accepted. PF showed no clinically relevant changes, though substantial individual variability was observed. In conclusion, the intervention was feasible, providing a supported alternative to on-site, especially in areas with difficult access to the training facilities. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126433 2026-01-01T00:00:00Z https://opendata.uni-halle.de//handle/1981185920/126432 Title: The influence of climate change and land use on plant populations : a demographic approach to understandig species dynamics in a changing environment Author(s): Andrzejak, Martin Abstract: Climate change is one of the primary drivers of biodiversity loss, potentially influencing every stage of a plant specie’s life and interacting with various biotic and abiotic factors. To predict and mitigate these impacts, it is crucial to identify the most vulnerable life stages and determine the most influential factors. First, I introduce the topics, outlining the concepts and the role of demographic studies as valuable tools. Second, I investigate how future climate conditions alter the balance between pollen limitation and resource limitation. Third, I explore how climate change and land use interact to influence the population growth rates of grassland species. Fourth, I examine the interactive effects of insect herbivores, pathogens, and climate change on plant population dynamics. Finally, I synthesize the findings, demonstrating how they contribute to our understanding of plant population dynamics and the interactions between climate change and biotic and abiotic factors. Thu, 01 Jan 2026 00:00:00 GMT https://opendata.uni-halle.de//handle/1981185920/126432 2026-01-01T00:00:00Z