Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/13848
Title: Zusammensetzung von IGF2BP1-enthaltenden Ribonukleoproteinkomplexen
Author(s): Baude, AnneLook up in the Integrated Authority File of the German National Library
Referee(s): Hüttelmaier, StefanLook up in the Integrated Authority File of the German National Library
Wahle, Elmar
Ostareck, Dirk H.Look up in the Integrated Authority File of the German National Library
Granting Institution: Martin-Luther-Universität Halle-Wittenberg
Issue Date: 2019
Extent: 1 Online-Ressource (115 Seiten)
Type: HochschulschriftLook up in the Integrated Authority File of the German National Library
Type: Doctoral thesis
Exam Date: 2019-03-15
Language: German
URN: urn:nbn:de:gbv:3:4-1981185920-139751
Subjects: Insulin-like-Growth-Factor-Binding-Protein-7Look up in the Integrated Authority File of the German National Library
RibonucleoproteineLook up in the Integrated Authority File of the German National Library
Abstract: Die posttranskriptionelle Kontrolle der Genregulation der mRNA wird im Wesentlichen durch spezifische Ribonukleoprotein-Komplexe (RNPs) gesteuert, in denen regulatorische Faktoren wie z. B. RNA-bindende Proteine (RBPs) und diverse Klassen von RNAs z.B. miRNAs mitwirken. In diesem Kontext beinflusst das RNA-bindende Protein IGF2BP1 die Stabilisierung der MYC-mRNA, indem es diese vor endonukleolytischem Abbau schützt. Darüber hinaus reguliert es auch die ACTB-mRNA Translation und steuert die subzelluläre Sortierung dieses Transkripts. Durch Regulation verschiedener Zieltranskripte fördert IGF2BP1 als onkofötales Protein auf diese Weise mesenchymale Zelleigenschaften wie Polarität, Proliferation und Migration während der Embryogenese sowie der Tumorbildung. Bislang ist jedoch noch nicht vollständig geklärt, mit welchen RBPs IGF2BP1 innerhalb des RNPs interagiert und inwieweit diese Interaktionen Einfluss auf die Expression der Zielgene nehmen.
The post-transcriptional control of the gene regulation of mRNA is essentially controlled by specific Ribonucleoprotein complexes (RNPs) in which regulatory factors such as RNA-binding proteins (RBPs) and various classes of RNAs, e.g. miRNAs, are involved. In this context, the RNA-binding protein IGF2BP1 influences the stabilization of MYC-mRNA by protecting it from endonucleolytic degradation. It also regulates ACTB-mRNA translation and subcellular sorting of this transcript. By regulating different target transcripts, IGF2BP1 as an oncofetal protein promotes mesenchymal cell properties such as polarity, proliferation and migration during embryogenesis and tumor formation. These regulatory processes are assumed to be interactions with other factors, in particular RBPs. However, it has not yet been fully clarified which RBPs IGF2BP1 interacts with within the RNP and to what extent these interactions influence the expression of the target genes.
URI: https://opendata.uni-halle.de//handle/1981185920/13975
http://dx.doi.org/10.25673/13848
Open Access: Open access publication
License: In Copyright
Appears in Collections:Biochemie

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