Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/111035
Title: Clinical importance of thoracal lymphadenopathy in COVID-19
Author(s): Meyer, Hans-JonasLook up in the Integrated Authority File of the German National Library
Melekh, Bohdan Ya.
Wienke, AndreasLook up in the Integrated Authority File of the German National Library
Borggrefe, JanLook up in the Integrated Authority File of the German National Library
Surov, AlexeyLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Background: Thoracal lymphadenopathy may predict prognosis in patients with coronavirus disease 2019 (COVID-19), albeit the reported data is inconclusive. The aim of the present analysis was to analyze the affected lymph node stations and the cumulative lymph node size derived from computed tomography (CT) for prediction of 30-day mortality in patients with COVID-19. Methods: The clinical database was retrospectively screened for patients with COVID-19 between 2020 and 2022. Overall, 177 patients (63 female, 35.6%) were included into the analysis. Thoracal lymphadenopathy was defined by short axis diameter above 10 mm. Cumulative lymph node size of the largest lymph nodes was calculated and the amount of affected lymph node stations was quantified. Results: Overall, 53 patients (29.9%) died within the 30-day observation period. 108 patients (61.0%) were admitted to the ICU and 91 patients needed to be intubated (51.4%). Overall, there were 130 patients with lymphadenopathy (73.4%). The mean number of affected lymph node levels were higher in non-survivors compared to survivors (mean, 4.0 vs 2.2, p < 0.001). The cumulative size was also higher in non-survivors compared to survivors (mean 55.9 mm versus 44.1 mm, p = 0.006). Presence of lymphadenopathy was associated with 30-day mortality in a multivariable analysis, OR = 2.99 (95% CI 1.20 – 7.43), p = 0.02. Conclusions: Thoracal lymphadenopathy comprising cumulative size and affected levels derived from CT images is associated with 30-day mortality in patients with COVID-19. COVID-19 patients presenting with thoracic lymphadenopathy should be considered as a risk group.
URI: https://opendata.uni-halle.de//handle/1981185920/112989
http://dx.doi.org/10.25673/111035
Open Access: Open access publication
License: (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0(CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0
Journal Title: Journal of infection and public health
Publisher: Elsevier
Publisher Place: Amsterdam [u.a.]
Volume: 16
Issue: 8
Original Publication: 10.1016/j.jiph.2023.05.031
Page Start: 1244
Page End: 1248
Appears in Collections:Open Access Publikationen der MLU

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