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http://dx.doi.org/10.25673/118837| Title: | Regulation of cellular function by mineralocorticoid receptors |
| Author(s): | Gadasheva, Yekaterina |
| Referee(s): | Großmann, Claudia Horstkorte, Rüdiger Heller, Regina |
| Granting Institution: | Martin Luther University Halle-Wittenberg |
| Issue Date: | 2025 |
| Extent: | 1 Online-Ressource (xi, 79 Seiten, Seite lxxx-lxxxviii) |
| Type: | Hochschulschrift |
| Type: | PhDThesis |
| Exam Date: | 2025-03-19 |
| Language: | English |
| URN: | urn:nbn:de:gbv:3:4-1981185920-1207952 |
| Abstract: | The mineralocorticoid receptor (MR), activated by aldosterone, influences renal physiology and also contributes to aging and cardiovascular pathology. This thesis investigates how MR activation alters cellular function, focusing on metabolic shifts, ER stress, autophagy, and cell death in an inducible HEK-MR model. Aldosterone stimulation increased glycolysis and triggered stress-response pathways. PDK4 was identified as an MR-target gene potentially involved in glucose metabolism and stress adaptation. Additionally, nitrosative stress enhanced MR translocation and induced the expression of genes associated with cardiac disease. These findings suggest elevated MR activity drives cellular changes contributing to MR-related pathophysiology |
| URI: | https://opendata.uni-halle.de//handle/1981185920/120795 http://dx.doi.org/10.25673/118837 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Appears in Collections: | Interne-Einreichungen |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Dissertation_MLU_2025_GadashevaYekaterina.pdf | 2.82 MB | Adobe PDF |  View/Open |