PS and PG-enriched extrudates and nanofibers for local anti-inflammatory therapies

Abstract

This thesis develops saturated phosphatidylglycerol (PG)-based drug delivery systems as oxidation-stable alternatives to unsaturated PGs for anti-inflammatory applications. Saturated PGs (e.g., DMPG) were formulated as mixed micelles (MMs) and twin-screw-extruded lipid implants to combine physicochemical stability with controlled drug release. These formulations were designed to enhance the solubilization of poorly water-soluble compounds and improve bioavailability, whereas the implants were developed for localized delivery with prolonged therapeutic action. In vitro cell culture studies demonstrated pronounced anti-inflammatory activity. For implant formulations, PG/SPC3/SL extrudates exhibited the highest stability under aqueous conditions. Overall, in vitro and in vivo release studies confirmed the feasibility of PG–SL MMs and PG-based extrudates as stable platforms with bioactivity suitable for local delivery and inflammation-related indications.