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http://dx.doi.org/10.25673/35667
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DC Field | Value | Language |
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dc.contributor.referee | Lorenz, Kerstin | - |
dc.contributor.referee | Rayes, Nada | - |
dc.contributor.referee | Holzer, Katharina | - |
dc.contributor.author | Elwerr, Malik | - |
dc.date.accessioned | 2021-02-03T12:30:10Z | - |
dc.date.available | 2021-02-03T12:30:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/35885 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/35667 | - |
dc.description.abstract | Calcitonin stimulation testing aims at defining the underlying type of c-cell disease (CCD) in order to customize appropriate timing and extent of surgery or consider observation. The importance of stimulation testing is widely accepted in hereditary CCD and the follow-up of MTC, while its role in sporadic forms is controversial. Importantly, calcium (Ca2+) stimulation testing lacks comparison to established recommendations based on reliable cut-off values using Pentagastrin (Pg). This study investigates the correlation of Ca2+- and Pg-stimulation testing in CCD. In a matched pair analysis, Pg- and Ca2+ -stimulation testing for calcitonin (Ct) was compared in 295 patients with c-cell hyperplasia (CCH) and with medullary thyroid cancer confined to the thyroid (Tx N0 M0) undergoing primary surgery. | ger |
dc.description.abstract | Calcitonin stimulation testing aims at defining the underlying type of c-cell disease (CCD) in order to customize appropriate timing and extent of surgery or consider observation. The importance of stimulation testing is widely accepted in hereditary CCD and the follow-up of MTC, while its role in sporadic forms is controversial. Importantly, calcium (Ca2+) stimulation testing lacks comparison to established recommendations based on reliable cut-off values using Pentagastrin (Pg). This study investigates the correlation of Ca2+- and Pg-stimulation testing in CCD. In a matched pair analysis, Pg- and Ca2+ -stimulation testing for calcitonin (Ct) was compared in 295 patients with c-cell hyperplasia (CCH) and with medullary thyroid cancer confined to the thyroid (Tx N0 M0) undergoing primary surgery. | eng |
dc.format.extent | 1 Online-Ressource (64 Seiten) | - |
dc.language.iso | ger | - |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | Calcium vs. Pentagastrin Stimulation bei der C-Zell-Erkrankung der Schilddrüse : eine Matched-Pair Analyse | ger |
dcterms.dateAccepted | 2020-11-20 | - |
dcterms.type | Hochschulschrift | - |
dc.type | PhDThesis | - |
dc.identifier.urn | urn:nbn:de:gbv:3:4-1981185920-358857 | - |
local.versionType | publishedVersion | - |
local.publisher.universityOrInstitution | Martin-Luther-Universität Halle-Wittenberg | - |
local.subject.keywords | Kalzitonin ist ein hoch spezifischer und sensitiver Marker für die C-Zell Erkrankung der Schilddrüse (CCD). Bei Vorliegen einer Hyperkalzitoninämie dient ein Stimulationsverfahren idealerweise zur Differenzierung zwischen einer C-Zell Hyperplasie (CCH) und einem medullären Schilddrüsenkarzinom (MTC). Das Testergebnis hat direkten Einfluss auf die geplante Therapie einer C-Zell-Erkrankung, indem die operative Therapie erweitert, eingeschränkt oder verschoben werden kann. Die vorliegende Arbeit beschreibt eine Matched-Pair Analyse, wobei die Kalzitoninstimulation mittels Pentagastrin und Calcium bei 295 Patienten mit einer CCH sowie einem nicht-metastasierten MTC (Tx N0 M0) bei Primäreingriffen verglichen wurden. | - |
local.subject.keywords | Schilddrüsenoperation, Medulläres Schilddrüsenkarzinom, C-Zell-Hyperplasie, Kalzitonin, Stimulation | - |
local.subject.keywords | Thyroid surgery, Medullary Thyroid cancer, C-Cell hyperplasia, calcitonin, stimulation | - |
local.openaccess | true | - |
dc.identifier.ppn | 1747213616 | - |
local.publication.country | XA-DE | - |
cbs.sru.importDate | 2021-02-03T12:29:03Z | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Interne-Einreichungen |
Files in This Item:
File | Description | Size | Format | |
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Diss. Elwerr - Bibliothek-1.pdf | 1.42 MB | Adobe PDF | ![]() View/Open |