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Title: Potential beneficial effects of vitamin D in coronary artery disease
Author(s): Legarth, Christian
Grimm, Daniela GabrieleLook up in the Integrated Authority File of the German National Library
Krüger, MarcusLook up in the Integrated Authority File of the German National Library
Infanger, ManfredLook up in the Integrated Authority File of the German National Library
Wehland, Markus
Issue Date: 2020
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-366751
Subjects: Vitamin D
Ischemic heart disease
Coronary artery disease
Abstract: Vitamin D plays a pivotal role in bone homeostasis and calcium metabolism. However, recent research has indicated additional beneficial effects of vitamin D on the cardiovascular system. This review aims to elucidate if vitamin D can be used as an add-on treatment in coronary artery disease (CAD). Large-scale epidemiological studies have found a significant inverse association between serum 25(OH)-vitamin D levels and the prevalence of essential hypertension. Likewise, epidemiological data have suggested plasma levels of vitamin D to be inversely correlated to cardiac injury after acute myocardial infarction (MI). Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-κB pathway to decrease CAD progression. This is suggested as a mechanistic link to explain how vitamin D may decrease vascular inflammation and atherosclerosis. A review of randomized controlled trials with vitamin D supplementation showed ambiguous results. This may partly be explained by heterogeneous study groups. It is suggested that subgroups of diabetic patients may benefit more from vitamin D supplementation. Moreover, some studies have indicated that calcitriol rather than cholecalciferol exerts more potent beneficial effects on atherosclerosis and CAD. Therefore, further studies are required to clarify these assumptions.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: DFG-Publikationsfonds 2020
Journal Title: Nutrients
Publisher: MDPI
Publisher Place: Basel
Volume: 12
Issue: 1
Original Publication: 10.3390/nu12010099
Page Start: 1
Page End: 22
Appears in Collections:Medizinische Fakultät (OA)

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