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Title: Deep brain stimulation of the subthalamic nucleus selectively modulates emotion recognition of facial stimuli in Parkinson’s patients
Author(s): Wagenbreth, CarolineLook up in the Integrated Authority File of the German National Library
Kuehne, Maria
Voges, JürgenLook up in the Integrated Authority File of the German National Library
Heinze, Hans-JochenLook up in the Integrated Authority File of the German National Library
Galazky, Imke
Zähle, TinoLook up in the Integrated Authority File of the German National Library
Issue Date: 2019
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-368001
Subjects: Parkinson’s disease
Deep brain stimulation
Subthalamic nucleus
Emotion processing
Affective priming
Abstract: Background: Diminished emotion recognition is a known symptom in Parkinson (PD) patients and subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to further deteriorate the processing of especially negative emotions. While emotion recognition generally refers to both, implicit and explicit processing, demonstrations of DBS-influences on implicit processing are sparse. In the present study, we assessed the impact of STN-DBS on explicit and implicit processing for emotional stimuli. Methods: Under STN-DBS ON and OFF, fourteen PD patients performed an implicit as well as an explicit emotional processing task. To assess implicit emotional processing, patients were tested with a lexical decision task (LTD) combined with an affective priming paradigm, which provides emotional content through the facial eye region. To assess explicit emotional processing, patients additionally explicitly rated the emotional status of eyes and words used in the implicit task. Results: DBS affected explicit emotional processing more than implicit processing with a more pronounced effect on error rates than on reaction speed. STN-DBS generally worsened implicit and explicit processing for disgust stimulus material but improved explicit processing of fear stimuli. Conclusions: This is the first study demonstrating influences of STN-DBS on explicit and implicit emotion processing in PD patients. While STN stimulation impeded the processing of disgust stimuli, it improved explicit discrimination of fear stimuli.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: DFG-Publikationsfonds 2019
Journal Title: Journal of Clinical Medicine
Publisher: MDPI
Publisher Place: Basel
Volume: 8
Issue: 9
Original Publication: 10.3390/jcm8091335
Page Start: 1
Page End: 14
Appears in Collections:Medizinische Fakultät (OA)

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