Please use this identifier to cite or link to this item:
Title: Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women : results from the CARLA cohort
Author(s): Ebert, Helen
Lacruz, Maria Elena
Kluttig, AlexanderLook up in the Integrated Authority File of the German National Library
Simm, Andreas
Greiser, Karin HalinaLook up in the Integrated Authority File of the German National Library
Tiller, DanielLook up in the Integrated Authority File of the German National Library
Kartschmit, Nadja
Mikolajczyk, RafaelLook up in the Integrated Authority File of the German National Library
Issue Date: 2019
Type: Article
Language: English
Abstract: Background Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum. Methods AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45–83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models. Results Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74–0.98 and OR = 0.86, 95%CI = 0.75–0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age. Conclusions We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfond MLU
Journal Title: BMC geriatrics
Publisher: BioMed Central
Publisher Place: London
Volume: 19
Issue: 299
Original Publication: 10.1186/s12877-019-1323-8
Appears in Collections:Open Access Publikationen der MLU

Files in This Item:
File Description SizeFormat 
s12877-019-1323-8.pdf689.13 kBAdobe PDFThumbnail