Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/38424
Title: 1H, 13C, and 15N Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein
Author(s): Lang, Andras
Kumar, Amit
Jirschitzka, Jan
Bordusa, Frank
Ohlenschläger, Oliver
Wiedemann, Christoph
Issue Date: 2020
Type: Article
Language: English
Abstract: The brain and acute leukemia cytoplasmic (BAALC; UniProt entry Q8WXS3) is a 180-residue-long human protein having six known isoforms. BAALC is expressed in either hematopoietic or neuroectodermal cells and its specific function is still to be revealed. However, as a presumably membrane-anchored protein at the cytoplasmic side it is speculated that BAALC exerts its function at the postsynaptic densities of certain neurons and might play a role in developing cytogenetically normal acute myeloid leukemia (CN-AML) when it is highly overexpressed by myeloid or lymphoid progenitor cells. In order to better understand the physiological role of BAALC and to provide the basis for a further molecular characterization of BAALC, we report here the 1H, 13C, and 15N resonance assignments for the backbone nuclei of its longest hematopoietic isoform (isoform 1). In addition, we present a 1HN and 15NH chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the 1H and 15N chemical shifts.
URI: https://opendata.uni-halle.de//handle/1981185920/38667
http://dx.doi.org/10.25673/38424
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Biomolecular NMR Assignments
Publisher: Springer
Publisher Place: Dordrecht
Volume: 14
Original Publication: 10.1007/s12104-020-09938-7
Page Start: 163
Page End: 168
Appears in Collections:Open Access Publikationen der MLU

Files in This Item:
File Description SizeFormat 
Lang2020_Article_1H13CAnd15NBackboneAssignments.pdf1.96 MBAdobe PDFThumbnail
View/Open