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Title: n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli
Author(s): Serbian, Immo
Prell, Erik
Fischer, Claudia
Deigner, Hans-Peter
Csuk, René
Issue Date: 2021
Type: Article
Language: English
Abstract: A convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n-propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside (8) was an excellent competitive inhibitor for the β-galactosidase from E. coli holding a Ki of 0.50 μM.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Medicinal Chemistry Research
Publisher: Birkhäuser Boston
Publisher Place: Cambridge, Mass. [u.a.]
Volume: 30
Original Publication: 10.1007/s00044-021-02715-8
Page Start: 1099
Page End: 1107
Appears in Collections:Open Access Publikationen der MLU

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