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Title: Synthesis and structure of azelastine-N-oxides
Author(s): Brandes, Benjamin
Halz, Jan H.
Merzweiler, Kurt
Deigner, Hans-Peter
Csuk, René
Issue Date: 2022
Type: Article
Language: English
Abstract: Azelastine is among the most frequently used drugs; however, knowledge and solid data about its metabolites are scarcely found in literature. Thus, microsomal oxidation of azelastine is thought to produce the corresponding N-oxides, However, until now these products had never been produced in significant amounts. By oxidation of azelastine with H2O2, these N-oxides were now prepared in racemic form for the first time and were fully characterized. Their structure was additionally confirmed by a single crystal X-ray analysis. Both N-oxides were found to be non-cytotoxic in SRB assays.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Journal of molecular structure
Publisher: Elsevier
Publisher Place: New York, NY [u.a.]
Volume: 1251
Original Publication: 10.1016/j.molstruc.2021.132033
Appears in Collections:Open Access Publikationen der MLU

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