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Title: Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer
Author(s): Sokolova, Olga
Naumann, Michael
Issue Date: 2021
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-1032389
Subjects: E3 ubiquitin ligases
Abstract: Infection with H. pylori induces a strong host cellular response represented by induction of a set of molecular signaling pathways, expression of proinflammatory cytokines and changes in proliferation. Chronic infection and inflammation accompanied by secretory dysfunction can result in the development of gastric metaplasia and gastric cancer. Currently, it has been determined that the regulation of many cellular processes involves ubiquitinylation of molecular effectors. The binding of ubiquitin allows the substrate to undergo a change in function, to interact within multimolecular signaling complexes and/ or to be degraded. Dysregulation of the ubiquitinylation machinery contributes to several pathologies, including cancer. It is not understood in detail how H. pylori impacts the ubiquitinylation of host substrate proteins. The aim of this review is to summarize the existing literature in this field, with an emphasis on the role of E3 ubiquitin ligases in host cell homeodynamics, gastric pathophysiology and gastric cancer.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Projekt DEAL 2021
Journal Title: Cellular and molecular life sciences
Publisher: Springer International Publishing AG
Publisher Place: Cham (ZG)
Volume: 78
Issue: 10
Original Publication: 10.1007/s00018-021-03816-8
Page Start: 4765
Page End: 4783
Appears in Collections:Medizinische Fakultät (OA)

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