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Title: Post-exercise pulsatility index indicates treatment effects in peripheral arterial occlusive disease (PAOD)
Author(s): Udelnow, Andrej A.Look up in the Integrated Authority File of the German National Library
Hawemann, Maria
Buschmann, IvoLook up in the Integrated Authority File of the German National Library
Meyer, FrankLook up in the Integrated Authority File of the German National Library
Halloul, ZuhirLook up in the Integrated Authority File of the German National Library
Issue Date: 2022
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-1032391
Subjects: Hemodynamic parameter
Peak systolic velocity (PSV)
End-diastolic velocity (EDV)
Minimal diastolic velocity (MD)
Time-averaged maximal velocities (TAMAX)
Resistance index (RI)
Resting measurement
Standard exercise test
Reintervention-free survival
Abstract: Summary Background Hypothesis: Post-exercise measurements better discriminate PAOD-patients from healthy persons and they more sensitively detect hemodynamic improvements after treatment procedures than resting measurements. Methods A total of 19 healthy volunteers and 23 consecutive PAOD-patients underwent measurements of peak systolic velocity (PSV), end-diastolic velocity (EDV), minimal diastolic velocity (MDV), time-averaged maximum velocities (TAMAX), resistance index (RI) and pulsatility index (PI) before and after a standard exercise test (at 1, 2, 3, 4 and 5 min) before and after treatment (incl. epidemiological data, PAOD risk factors and comorbidities). Results In resting values, healthy persons and PAODpatients did not differ significantly in any of the hemodynamic parameters. PSV increased after treatment in PAOD-patients by 5 cm/s (paired t-test, p: 0.025); however, when the amplitude of autoregulatory changes related to the resting values were calculated, PAOD-patients showed clearly less hemodynamic changes after exercise than healthy persons (p: 0.04; 0.002; <0.001 for PSV, TAMAX and PI, resp.). The time course after exercise was compared by repeated measures of ANOVA. Healthy persons differed significantly in PI, RI and PSV from PAOD patients before and after treatment (p<0.001 each). The PAODpatients revealed a significantly improved PI after treatment (p: 0.042). The only factor contributing significantly to PI independently from grouping was direct arterial vascularization as compared to discontinuous effects by an obstructed arterial tree. Conclusion Healthy persons cannot be well differentiated from PAOD-patients solely by hemodynamics at rest but by characteristic changes after standard exercise. Treatment effects are reflected by higher PIvalues after exercise.
Open Access: Open access publication
License: (CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0(CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0
Sponsor/Funder: Projekt DEAL 2021
Journal Title: Wiener klinische Wochenschrift
Publisher: Springer
Publisher Place: Wien
Volume: 134
Issue: 3/4
Original Publication: 10.1007/s00508-021-01818-x
Page Start: 148
Page End: 155
Appears in Collections:Medizinische Fakultät (OA)

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