Determination of Amlodipine in Pharmaceutical Formulation by Charge Transfer Complex Method

Abstract

Charge transfer complexes were attended by the interaction of Schiff base (amlodipine + Picolin aldehyde) with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) to create a Compound that produced the maximum absorption at a wavelength of 436 nm by selecting the optimal conditions for the interaction between the two compounds which were adopted in subsequent experiments. The study covers the development of a straightforward and precise spectrophotometry for the measurement of amlodipine (AML) in pharmaceutical formulations and pure forms. The molar absorption rate was 1.4556×104 l.mol-1.cm-1, the correlation coefficient was 0.9981, the sandal sensitivity was 0.0281.μg.cm-2, And the Beer's law limit was 5􀂱40 μg.ml1. When this technique was used to estimate the amount of AML in pharmaceuticals, the composition of the resultant compound revealed that the detection limit (0.2596 μg.ml-1). The quantitative limit (0.7865μg.ml-1), and the Rec value (%103.1124-96.8260) were all within the range of 0.2257-0.6258. Additionally, AML measurement approach has proven effectively. Characterized complexes by U.V, FTIR and Spectrum of Mass.