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Title: Hippocampal and cortical neuroplasticity and functional changes induced by vestibular system stimulation through various methods of balance training
Author(s): Đorđević, Miloš
Referee(s): Schreiber, Stefanie
Falkenstein, Michael
Granting Institution: Otto-von-Guericke-Universität Magdeburg
Issue Date: 2018
Type: PhDThesis
Exam Date: 2019
Language: English
Publisher: Otto-von-Guericke-Universität Magdeburg
URN: urn:nbn:de:gbv:ma9:1-1981185920-141479
Subjects: Neuronale Plastizität
Abstract: The aim of this thesis was to investigate whether different types of vestibular system stimulation through balance training can have beneficial effects on vestibular-dependent path integration and balance abilities as well as on neuroplasticity in corresponding gray matter regions, especially in the hippocampal formation. For this reason, three separate studies were organized: 1) 3-month longitudinal slacklining training study with young subjects (18-35 years), b) cross-sectional study on professional ballet dancers (18-35 years) and c) 18-month longitudinal sportive dancing study with older subjects (60-85 years). The results showed significant improvements in vestibular-dependent path integration and balance abilities, along with the changes in gray matter in the hippocampal formation (hippocampus, parahipocampus) and other cortical regions in groups where a voxel-based morphometric (VBM) analysis was performed (ballet dancers and sportive dancers). These results show that strong stimulation of the vestibular system by behavioral interventions can lead to structural (neuroanatomical) and functional benefits. Possible implications of the findings are in the prevention of dementia and in the fall prevention.
Open Access: Open access publication
License: (CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0(CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0
Appears in Collections:Medizinische Fakultät

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