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Title: Resolved influenza A virus infection has extended effects on lung homeostasis and attenuates allergic airway inflammation in a mouse model
Author(s): Wu, Qingyu
Jorde, Ilka
Kershaw, OliviaLook up in the Integrated Authority File of the German National Library
Jeron, AndreasLook up in the Integrated Authority File of the German National Library
Bruder, DunjaLook up in the Integrated Authority File of the German National Library
Schreiber, JensLook up in the Integrated Authority File of the German National Library
Stegemann-Koniszewski, Sabine
Issue Date: 2020
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-366279
Subjects: Influenza A virus
Allergic asthma
Allergic airway inflammation
Respiratory immune regulation
Pro-inflammatory cytokines
Abstract: Allergic airway inflammation (AAI) involves T helper cell type 2 (Th2) and pro-inflammatory responses to aeroallergens and many predisposing factors remain elusive. Influenza A virus (IAV) is a major human pathogen that causes acute respiratory infections and induces specific immune responses essential for viral clearance and resolution of the infection. Beyond acute infection, IAV has been shown to persistently affect lung homeostasis and respiratory immunity. Here we asked how resolved IAV infection affects subsequently induced AAI. Mice infected with a sublethal dose of IAV were sensitized and challenged in an ovalbumin mediated mouse model for AAI after resolution of the acute viral infection. Histological changes, respiratory leukocytes, cytokines and airway hyperreactivity were analyzed in resolved IAV infection alone and in AAI with and without previous IAV infection. More than five weeks after infection, we detected persistent pneumonia with increased activated CD4+ and CD8+ lymphocytes as well as dendritic cells and MHCII expressing macrophages in the lung. Resolved IAV infection significantly affected subsequently induced AAI on different levels including morphological changes, respiratory leukocytes and lymphocytes as well as the pro-inflammatory cytokine responses, which was clearly diminished. We conclude that IAV has exceptional persisting effects on respiratory immunity with substantial consequences for subsequently induced AAI.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: DFG-Publikationsfonds 2020
Journal Title: Microorganisms
Publisher: MDPI
Publisher Place: Basel
Volume: 8
Issue: 12
Original Publication: 10.3390/microorganisms8121878
Page Start: 1
Page End: 20
Appears in Collections:Medizinische Fakultät (OA)

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