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http://dx.doi.org/10.25673/36443
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DC Field | Value | Language |
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dc.contributor.author | Legarth, Christian | - |
dc.contributor.author | Grimm, Daniela Gabriele | - |
dc.contributor.author | Krüger, Marcus | - |
dc.contributor.author | Infanger, Manfred | - |
dc.contributor.author | Wehland, Markus | - |
dc.date.accessioned | 2021-04-28T12:39:07Z | - |
dc.date.available | 2021-04-28T12:39:07Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/36675 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/36443 | - |
dc.description.abstract | Vitamin D plays a pivotal role in bone homeostasis and calcium metabolism. However, recent research has indicated additional beneficial effects of vitamin D on the cardiovascular system. This review aims to elucidate if vitamin D can be used as an add-on treatment in coronary artery disease (CAD). Large-scale epidemiological studies have found a significant inverse association between serum 25(OH)-vitamin D levels and the prevalence of essential hypertension. Likewise, epidemiological data have suggested plasma levels of vitamin D to be inversely correlated to cardiac injury after acute myocardial infarction (MI). Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-κB pathway to decrease CAD progression. This is suggested as a mechanistic link to explain how vitamin D may decrease vascular inflammation and atherosclerosis. A review of randomized controlled trials with vitamin D supplementation showed ambiguous results. This may partly be explained by heterogeneous study groups. It is suggested that subgroups of diabetic patients may benefit more from vitamin D supplementation. Moreover, some studies have indicated that calcitriol rather than cholecalciferol exerts more potent beneficial effects on atherosclerosis and CAD. Therefore, further studies are required to clarify these assumptions. | eng |
dc.description.sponsorship | DFG-Publikationsfonds 2020 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | http://www.mdpi.com/journal/nutrients | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Vitamin D | eng |
dc.subject | Cholecalciferol | eng |
dc.subject | Ischemic heart disease | eng |
dc.subject | Coronary artery disease | eng |
dc.subject.ddc | 610.72 | - |
dc.title | Potential beneficial effects of vitamin D in coronary artery disease | eng |
dc.type | Article | - |
dc.identifier.urn | urn:nbn:de:gbv:ma9:1-1981185920-366751 | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Nutrients | - |
local.bibliographicCitation.volume | 12 | - |
local.bibliographicCitation.issue | 1 | - |
local.bibliographicCitation.pagestart | 1 | - |
local.bibliographicCitation.pageend | 22 | - |
local.bibliographicCitation.publishername | MDPI | - |
local.bibliographicCitation.publisherplace | Basel | - |
local.bibliographicCitation.doi | 10.3390/nu12010099 | - |
local.openaccess | true | - |
dc.identifier.ppn | 1687172986 | - |
local.bibliographicCitation.year | 2020 | - |
cbs.sru.importDate | 2021-04-28T12:34:16Z | - |
local.bibliographicCitation | Enthalten in Nutrients - Basel : MDPI, 2009 | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Medizinische Fakultät (OA) |
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File | Description | Size | Format | |
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Legarth et al._Potential_2020.pdf | Zweitveröffentlichung | 880.08 kB | Adobe PDF | ![]() View/Open |