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Title: Invited review : the spectrum of age‐related small vessel diseases : potential overlap and interactions of amyloid and nonamyloid vasculopathies
Author(s): Schreiber, Stefanie
Wilisch-Neumann, Annette
Schreiber, Frank
Assmann, Anne
Scheumann, Vincent
Perosa, Valentina
Jandke, Solveig
Mawrin, ChristianLook up in the Integrated Authority File of the German National Library
Carare, Roxana O.
Werring, David J.Look up in the Integrated Authority File of the German National Library
Issue Date: 2020
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-418588
Subjects: Deep perforator arteriopathy (DPA)
Amyloid vasculopathies
Nonamyloid vasculopathies
Abstract: Deep perforator arteriopathy (DPA) and cerebral amyloid angiopathy (CAA) are the commonest known cerebral small vessel diseases (CSVD), which cause ischaemic stroke, intracebral haemorrhage (ICH) and vascular cognitive impairment (VCI). While thus far mainly considered as separate entities, we here propose that DPA and CAA share similarities, overlap and interact, so that ‘pure’ DPA or CAA are extremes along a continuum of age-related small vessel pathologies. We suggest blood-brain barrier (BBB) breakdown, endothelial damage and impaired perivascular β-amyloid (Aβ) drainage are hallmark common mechanisms connecting DPA and CAA. We also suggest a need for new biomarkers (e.g. high-resolution imaging) to deepen understanding of the complex relationships between DPA and CAA.
Open Access: Open access publication
License: (CC BY-NC 4.0) Creative Commons Attribution NonCommercial 4.0(CC BY-NC 4.0) Creative Commons Attribution NonCommercial 4.0
Sponsor/Funder: Projekt DEAL 2019
Journal Title: Neuropathology & applied neurobiology
Publisher: Wiley-Blackwell
Publisher Place: Oxford [u.a.]
Volume: 46
Issue: 3
Original Publication: 10.1111/nan.12576
Page Start: 219
Page End: 239
Appears in Collections:Medizinische Fakultät (OA)

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