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Title: A novel alloy development approach : biomedical equiatomic Ta-Nb-Ti alloy
Author(s): Regenberg, Maximilian
Schmelzer, Janett
Hasemann, GeorgLook up in the Integrated Authority File of the German National Library
Bertrand, JessicaLook up in the Integrated Authority File of the German National Library
Krüger, ManjaLook up in the Integrated Authority File of the German National Library
Issue Date: 2021
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-801111
Subjects: High-entropy alloys
Refractory elements
Biomedical materials
Cell cultivation
Abstract: In the present manuscript, we report on the properties of an equiatomic Ta-Nb-Ti alloy as the basis for a novel, biomedical, multi-component alloy development. The alloy was produced using an arc melting furnace under Ar atmosphere, metallographically prepared, and investigated respectively. Furthermore, the alloy produced, as well as samples of elemental Ta, Nb, alloy Co- 28Cr-6Mo, and alloy Ti-6Al-4V, were prepared with defined 1200 grit SiC grinding paper. The topography of the surfaces was evaluated using confocal microscopy and contact angle measurements subsequently. Afterwards, the biocompatibility of the novel alloy Ta-Nb-Ti was evaluated by means of cell (osteoblast) attachment as well as monocyte inflammatory response analysis. First results indicate competitive osteoblast attachment, as well as comparable expressions of fibrosis markers in comparison to conventionally used biomedical materials. In addition, the Ta-Nb-Ti alloy showed a markedly reduced inflammatory capacity, indicating a high potential for use as a prospective biomedical material.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: OVGU-Publikationsfonds 2021
Journal Title: Metals
Publisher: MDPI
Publisher Place: Basel
Volume: 11
Issue: 11
Original Publication: 10.3390/met11111778
Page Start: 1
Page End: 12
Appears in Collections:Fakultät für Maschinenbau (OA)

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