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Title: Apparent diffusion coefficient can predict therapy response of hepatocellular carcinoma to transcatheter arterial chemoembolization
Author(s): Drewes, Ralph
Heinze, Constanze
Pech, MaciejLook up in the Integrated Authority File of the German National Library
Powerski, Maciej
Woidacki, Katja
Wienke, AndreasLook up in the Integrated Authority File of the German National Library
Surov, Alexey
Omari, Jazan
Issue Date: 2021
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-883128
Subjects: Hepatocellular carcinoma
Transcatheter arterial chemoembolization
Magnetic resonance imaging
Apparent diffusion coefficient
Treatment response
Abstract: Aim: The goal of this meta-analysis was to assess the apparent diffusion coefficient (ADC) as a pre- and posttreatment (ADC value changes [ΔADC]) predictive imaging biomarker of response to transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Methods: Scopus database, Embase database, and MEDLINE library were scanned for connections between pre- and posttreatment ADC values of HCC and response to TACE. Six studies qualified for inclusion. The following parameters were collected: authors, publication year, study design, number of patients, drugs for TACE, mean ADC value, standard deviation, measure method, b values, and Tesla strength. The Quality Assessment of Diagnostic Studies 2 instrument was employed to check the methodological quality of each study. The meta-analysis was performed by utilizing RevMan 5.3 software. DerSimonian and Laird randomeffects models with inverse-variance were used to regard heterogeneity. The mean ADC values and 95% confidence intervals were computed. Results: Six studies (n = 271 patients with 293 HCC nodules) were included. The pretreatment mean ADC in the responder group was 1.20 × 10−3 mm2/s (0.98, 1.42) and 1.14 × 10−3 mm2/s (0.89, 1.39) in the nonresponder group. The analysis of post-TACE ΔADC revealed a threshold of ≥20% to identify treatment responders. No suitable pretreatment ADC threshold to predict therapy response or discriminate between responders and nonresponders before therapy could be discovered. Conclusion: ΔADC can facilitate early objective response evaluation through post-therapeutic ADC alterations ≥20%. Pretreatment ADC cannot predict response to TACE.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Transformationsvertrag
Journal Title: Digestive diseases
Publisher: Karger
Publisher Place: Basel
Original Publication: 10.1159/000520716
Page Start: 1
Page End: 11
Appears in Collections:Medizinische Fakultät (OA)

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