Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/36366
Title: | Breast cancer cells in microgravity : new aspects for cancer research |
Author(s): | Nassef, Mohamed Zakaria Melnik, Daniela Kopp, Sascha Sahana, Jayashree Infanger, Manfred Lützenberg, Ronald Relja, Borna Wehland, Markus Grimm, Daniela Gabriele Krüger, Marcus |
Issue Date: | 2020 |
Type: | Article |
Language: | English |
URN: | urn:nbn:de:gbv:ma9:1-1981185920-365989 |
Subjects: | Metastasis Proliferation Apoptosis Cell adhesion In vitro 3D tumor model Cancer therapeutic targets |
Abstract: | Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically during recent decades. Dismissed as an “unsolved problem of the last century”, breast cancer still represents a health burden with no effective solution identified so far. Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies. Numerous studies have indicated that µg has a great impact on cancer cells; by influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and to study various processes of cancer progression. In summary, µg has become an important tool in understanding and influencing breast cancer biology. |
URI: | https://opendata.uni-halle.de//handle/1981185920/36598 http://dx.doi.org/10.25673/36366 |
Open Access: | Open access publication |
License: | (CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0 |
Sponsor/Funder: | DFG-Publikationsfonds 2020 |
Journal Title: | International journal of molecular sciences |
Publisher: | Molecular Diversity Preservation International |
Publisher Place: | Basel |
Volume: | 21 |
Issue: | 19 |
Original Publication: | 10.3390/ijms21197345 |
Page Start: | 1 |
Page End: | 22 |
Appears in Collections: | Medizinische Fakultät (OA) |
Files in This Item:
File | Description | Size | Format | |
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Nassef et al._Breast_2020.pdf | Zweitveröffentlichung | 2.83 MB | Adobe PDF | View/Open |