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Titel: A multiwell applicator for conformal brachytherapy of superficial skin tumors : a simulation study
Autor(en): Pashazadeh, AliIn der Gemeinsamen Normdatei der DNB nachschlagen
Robatjazi, Mostafa
Castro, Nathan J.
Friebe, MichaelIn der Gemeinsamen Normdatei der DNB nachschlagen
Erscheinungsdatum: 2020
Art: Artikel
Sprache: Englisch
URN: urn:nbn:de:gbv:ma9:1-1981185920-440867
Schlagwörter: Brachytherapy
Skin tumors
Skin brachytherapy applicator
3D printing technology
Zusammenfassung: Background Brachytherapy of thin skin tumors using beta particles can protect underlying sensitive structures such as the bone because of the rapid dose falloff of this type of radiation in tissue. The current work describes a skin brachytherapy applicator, based on beta radiation, that can provide the needed cell-killing radiation dose matched to the shape of individual skin tumors. Materials and methods The applicator and its template were fabricated using 3D printing technology. Any clinically approved beta-emitting isotope in the form of a radioactive gel could theoretically be used in this applicator. Monte Carlo simulations were employed to study the capability of the applicator in conforming dose distribution based on the shape of the tumor. Dose profile in the shallow depth, transverse dose profiles at different depths, and the percent depth dose from this applicator were calculated. The radioisotope of choice for our calculations was Yttrium-90 (Y-90). Results Using the proposed applicator, it is possible to create a desired dose profile matching the tumor surface shape. Conclusion The short-range of the beta radiation, together with the dose conforming capability of the applicator, may lead to minimal interactions with the healthy tissue around the skin lesion.
URI: https://opendata.uni-halle.de//handle/1981185920/44086
http://dx.doi.org/10.25673/42132
Open-Access: Open-Access-Publikation
Nutzungslizenz: (CC BY 4.0) Creative Commons Namensnennung 4.0 International(CC BY 4.0) Creative Commons Namensnennung 4.0 International
Sponsor/Geldgeber: Projekt DEAL 2019
Journal Titel: Skin research & technology
Verlag: Wiley-Blackwell
Verlagsort: Oxford [u.a.]
Band: 26
Heft: 4
Originalveröffentlichung: 10.1111/srt.12826
Seitenanfang: 537
Seitenende: 541
Enthalten in den Sammlungen:Medizinische Fakultät (OA)

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