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http://dx.doi.org/10.25673/71800
Titel: | Clinical risk predictors in atrial fibrillation patients following successful coronary stenting : ENTRUST-AF PCI sub-analysis |
Autor(en): | Goette, Andreas![]() Eckardt, Lars ![]() Valgimigli, Marco ![]() Lewalter, Thorsten ![]() Laeis, Petra Reimitz, Paul-Egbert Smolnik, Rüdiger ![]() Zierhut, Wolfgang Tijssen, Jan G. Vranckx, Pascal ![]() |
Erscheinungsdatum: | 2021 |
Art: | Artikel |
Sprache: | Englisch |
URN: | urn:nbn:de:gbv:ma9:1-1981185920-737520 |
Schlagwörter: | Atrial fibrillation Coronary stenting NOACs CHA2DS2-VASc Edoxaban |
Zusammenfassung: | Aims This subgroup analysis of the ENTRUST-AF PCI trial (ClinicalTrials.gov Identifier: NCT02866175; Date of registration: August 2016) evaluated type of AF, and CHA2DS2- VASc score parameters as predictors for clinical outcome. Methods Patients were randomly assigned after percutaneous coronary intervention (PCI) to either edoxaban (60 mg/30 mg once daily [OD]; n = 751) plus a P2Y12 inhibitor for 12 months or a vitamin K antagonist [VKA] (n = 755) plus a P2Y12 inhibitor and aspirin (100 mg OD, for 1–12 months). The primary outcome was a composite of major/clinically relevant non-major bleeding (CRNM) within 12 months. The composite efficacy endpoint consisted of cardiovascular death, stroke, systemic embolic events, myocardial infarction (MI), and definite stent thrombosis. Results Major/CRNM bleeding event rates were 20.7%/year and 25.6%/year with edoxaban and warfarin, respectively (HR [95% CI]: 0.83 [0.654–1.047]). The event rates of composite outcome were 7.26%/year and 6.86%/year, respectively (HR [95% CI]): 1.06 [0.711–1.587]), and of overall net clinical benefit were 12.48%/year and 12.80%/year, respectively (HR [(95% CI]: 0.99 [(0.730; 1.343]). Increasing CHA2DS2- VASc score was associated with increased rates of all outcomes. CHA2DS2- VASc score ≥ 5 was a marker for stent thrombosis. Paroxysmal AF was associated with a higher occurrence of MI (4.87% versus 2.01%, p = 0.0024). Conclusion After PCI in AF patients, increasing CHA2DS2- VASc score was associated with increased bleeding rates and CHA2DS2- VASc score (≥ 5) predicted the occurrence of stent thrombosis. Paroxysmal AF was associated with MI. These findings may have important clinical implications in AF patients. |
URI: | https://opendata.uni-halle.de//handle/1981185920/73752 http://dx.doi.org/10.25673/71800 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Sponsor/Geldgeber: | Projekt DEAL 2020 |
Journal Titel: | Clinical research in cardiology |
Verlag: | Springer |
Verlagsort: | Berlin |
Band: | 110 |
Heft: | 6 |
Originalveröffentlichung: | 10.1007/s00392-020-01760-4 |
Seitenanfang: | 831 |
Seitenende: | 840 |
Enthalten in den Sammlungen: | Medizinische Fakultät (OA) |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Goette et al._Clinical risk_2021.pdf | Zweitveröffentlichung | 1.28 MB | Adobe PDF | ![]() Öffnen/Anzeigen |