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http://dx.doi.org/10.25673/92721
Titel: | TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-[kappa]B pathways |
Autor(en): | Maubach, Gunter![]() Lim, Michelle C. C. Sokolova, Olga Backert, Steffen ![]() Meyer, Thomas F. ![]() Naumann, Michael |
Erscheinungsdatum: | 2021 |
Art: | Artikel |
Sprache: | Englisch |
URN: | urn:nbn:de:gbv:ma9:1-1981185920-946772 |
Schlagwörter: | ALPK1 cIAP1 NIK TRAF |
Zusammenfassung: | Helicobacter pylori infection constitutes one of the major risk factors for the development of gastric diseases including gastric cancer. The activation of nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-kappaB) via classical and alternative pathways is a hallmark of H. pylori infection leading to inflammation in gastric epithelial cells. Tumor necrosis factor receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain (TIFA) was previously suggested to trigger classical NF-kappaB activation, but its role in alternative NF-kappaB activation remains unexplored. Here, we identify TRAF6 and TRAF2 as binding partners of TIFA, contributing to the formation of TIFAsomes upon H. pylori infection. Importantly, the TIFA/TRAF6 interaction enables binding of TGFbactivated kinase 1 (TAK1), leading to the activation of classical NF-kappaB signaling, while the TIFA/TRAF2 interaction causes the transient displacement of cellular inhibitor of apoptosis 1 (cIAP1) from TRAF2, and proteasomal degradation of cIAP1, to facilitate the activation of the alternative NF-kappaB pathway. Our findings therefore establish a dual function of TIFA in the activation of classical and alternative NF-kappaB signaling in H. pylori-infected gastric epithelial cells. |
URI: | https://opendata.uni-halle.de//handle/1981185920/94677 http://dx.doi.org/10.25673/92721 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Sponsor/Geldgeber: | Projekt DEAL 2021 |
Journal Titel: | EMBO reports |
Verlag: | EMBO Press |
Verlagsort: | Heidelberg |
Band: | 22 |
Heft: | 9 |
Originalveröffentlichung: | 10.15252/embr.202152878 |
Seitenanfang: | 1 |
Seitenende: | 12 |
Enthalten in den Sammlungen: | Medizinische Fakultät (OA) |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Maubach et al._TIFA has dual_2021.pdf | Zweitveröffentlichung | 3.93 MB | Adobe PDF | ![]() Öffnen/Anzeigen |