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http://dx.doi.org/10.25673/101558
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DC Field | Value | Language |
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dc.contributor.author | Allweyer, Martin | - |
dc.contributor.author | Emde, Matthias | - |
dc.contributor.author | Bähr, Ina | - |
dc.contributor.author | Spielmann, Julia | - |
dc.contributor.author | Bieramperl, Philipp | - |
dc.contributor.author | Naujoks, Wiebke | - |
dc.contributor.author | Kielstein, Heike | - |
dc.date.accessioned | 2023-03-29T11:39:54Z | - |
dc.date.available | 2023-03-29T11:39:54Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/103516 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/101558 | - |
dc.description.abstract | Diet-induced obesity (DIO) mice models are commonly used to investigate obesity-related health problems. Until now, only sparse data exist on the influence of DIO on behavior and stress hormones in mice. The present study investigates high-fat DIO with two different feeding regimes on behavioral parameters in mice. Various behavioral tests (open field, elevated plus maze, social interaction, hotplate) were performed with female BALB/c and male C57BL/6 mice after a feeding period of twelve weeks (restrictive vs. ad libitum and normal-fat diet vs. high-fat diet) to investigate levels of anxiety and aggression. BALB/c mice were DIO-resistant and therefore the prerequisite for the behavior analyses was not attained. C57BL/6 mice fed a high-fat diet had a significantly higher body weight and fat mass compared to C57BL/6 mice fed a control diet. Interestingly, the DIO C57BL/6 mice showed no changes in their aggression- or anxiety-related behavior but showed a significant change in the anxiety index. This was probably due to a lower activity level, as other ethological parameters did not show an altered anxiety-related behavior. In the ad libitum-fed DIO group, the highest corticosterone level was detected. Changes due to the feeding regime (restrictive vs. ad libitum) were not observed. These results provide a possible hint to a bias in the investigation of DIO-related health problems in laboratory animal experiments, which may be influenced by the lower activity level. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 599 | - |
dc.title | Investigation of behavior and plasma levels of corticosterone in restrictive- and ad libitum-fed diet-induced obese mice | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Nutrients | - |
local.bibliographicCitation.volume | 14 | - |
local.bibliographicCitation.issue | 9 | - |
local.bibliographicCitation.publishername | MDPI | - |
local.bibliographicCitation.publisherplace | Basel | - |
local.bibliographicCitation.doi | 10.3390/nu14091746 | - |
local.subject.keywords | obesity, behavior, mice, activity, anxiety, aggression | - |
local.openaccess | true | - |
dc.identifier.ppn | 1801399875 | - |
local.bibliographicCitation.year | 2022 | - |
cbs.sru.importDate | 2023-03-29T11:38:41Z | - |
local.bibliographicCitation | Enthalten in Nutrients - Basel : MDPI, 2009 | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
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File | Description | Size | Format | |
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nutrients-14-01746.pdf | 1.55 MB | Adobe PDF | ![]() View/Open |