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http://dx.doi.org/10.25673/101712
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DC Element | Wert | Sprache |
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dc.contributor.author | Huemer, Marie-Theres | - |
dc.contributor.author | Kluttig, Alexander | - |
dc.contributor.author | Mikolajczyk, Rafael | - |
dc.date.accessioned | 2023-04-03T12:44:07Z | - |
dc.date.available | 2023-04-03T12:44:07Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/103659 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/101712 | - |
dc.description.abstract | Background: The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. Objective: Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample. Methods: We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19–75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65–93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality. Results: Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality. Conclusions Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort : a comparison to the EWGSOP2 cut-off points | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Age & ageing | - |
local.bibliographicCitation.volume | 52 | - |
local.bibliographicCitation.issue | 1 | - |
local.bibliographicCitation.publishername | Oxford Univ. Press | - |
local.bibliographicCitation.publisherplace | Oxford | - |
local.bibliographicCitation.doi | 10.1093/ageing/afac324 | - |
local.subject.keywords | gripstrength,probablesarcopenia,EuropeanWorkingGrouponSarcopeniainOlderPeople(EWGSOP),mortality,cut-offpoints | - |
local.openaccess | true | - |
dc.identifier.ppn | 1841061557 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2023-04-03T12:43:05Z | - |
local.bibliographicCitation | Enthalten in Age & ageing - Oxford : Oxford Univ. Press, 1972 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
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afac324.pdf | 596.77 kB | Adobe PDF | ![]() Öffnen/Anzeigen |