Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.25673/101736Langanzeige der Metadaten
| DC Element | Wert | Sprache |
|---|---|---|
| dc.contributor.author | Heise, Niels V. | - |
| dc.contributor.author | Heisig, Julia | - |
| dc.contributor.author | Höhlich, Linda | - |
| dc.contributor.author | Hoenke, Sophie | - |
| dc.contributor.author | Csuk, René | - |
| dc.date.accessioned | 2023-04-04T12:22:08Z | - |
| dc.date.available | 2023-04-04T12:22:08Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/103683 | - |
| dc.identifier.uri | http://dx.doi.org/10.25673/101736 | - |
| dc.description.abstract | 36 substituted benzylamides were prepared starting from maslinic acid, bredemolic acid, and augustic acid and evaluated for their cytotoxicity in SRB assays employing several human tumor cell lines as well as non-malignant fibroblasts. Thereby, the benzylamides of maslinic acid, however, were found to be more cytotoxic than those obtained from augustic acid or bredemolic acid. The best compound (18, derived from maslinic acid) showed an EC50 value of 1.3 μM against A375 melanoma cells. Additional staining experiments revealed that this compound acted rather by apoptosis than by necrosis. | eng |
| dc.language.iso | eng | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject.ddc | 540 | - |
| dc.title | Synthesis and cytotoxicity of diastereomeric benzylamides derived from maslinic acid, augustic acid and bredemolic acid | eng |
| dc.type | Article | - |
| local.versionType | publishedVersion | - |
| local.bibliographicCitation.journaltitle | Results in chemistry | - |
| local.bibliographicCitation.volume | 5 | - |
| local.bibliographicCitation.publishername | Elsevier | - |
| local.bibliographicCitation.publisherplace | Amsterdam | - |
| local.bibliographicCitation.doi | 10.1016/j.rechem.2023.100805 | - |
| local.subject.keywords | Bredemolic acid, Maslinic acid, Augustic acid, Cytotoxicity, Amides | - |
| local.openaccess | true | - |
| dc.identifier.ppn | 1841208531 | - |
| local.bibliographicCitation.year | 2023 | - |
| cbs.sru.importDate | 2023-04-04T12:21:36Z | - |
| local.bibliographicCitation | Enthalten in Results in chemistry - Amsterdam : Elsevier, 2019 | - |
| local.accessrights.dnb | free | - |
| Enthalten in den Sammlungen: | Open Access Publikationen der MLU | |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 1-s2.0-S2211715623000449-main.pdf | 2.44 MB | Adobe PDF |  Öffnen/Anzeigen |