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dc.contributor.authorHeise, Niels V.-
dc.contributor.authorHeisig, Julia-
dc.contributor.authorHöhlich, Linda-
dc.contributor.authorHoenke, Sophie-
dc.contributor.authorCsuk, René-
dc.date.accessioned2023-04-04T12:22:08Z-
dc.date.available2023-04-04T12:22:08Z-
dc.date.issued2023-
dc.identifier.urihttps://opendata.uni-halle.de//handle/1981185920/103683-
dc.identifier.urihttp://dx.doi.org/10.25673/101736-
dc.description.abstract36 substituted benzylamides were prepared starting from maslinic acid, bredemolic acid, and augustic acid and evaluated for their cytotoxicity in SRB assays employing several human tumor cell lines as well as non-malignant fibroblasts. Thereby, the benzylamides of maslinic acid, however, were found to be more cytotoxic than those obtained from augustic acid or bredemolic acid. The best compound (18, derived from maslinic acid) showed an EC50 value of 1.3 μM against A375 melanoma cells. Additional staining experiments revealed that this compound acted rather by apoptosis than by necrosis.eng
dc.language.isoeng-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc540-
dc.titleSynthesis and cytotoxicity of diastereomeric benzylamides derived from maslinic acid, augustic acid and bredemolic acideng
dc.typeArticle-
local.versionTypepublishedVersion-
local.bibliographicCitation.journaltitleResults in chemistry-
local.bibliographicCitation.volume5-
local.bibliographicCitation.publishernameElsevier-
local.bibliographicCitation.publisherplaceAmsterdam-
local.bibliographicCitation.doi10.1016/j.rechem.2023.100805-
local.subject.keywordsBredemolic acid, Maslinic acid, Augustic acid, Cytotoxicity, Amides-
local.openaccesstrue-
dc.identifier.ppn1841208531-
local.bibliographicCitation.year2023-
cbs.sru.importDate2023-04-04T12:21:36Z-
local.bibliographicCitationEnthalten in Results in chemistry - Amsterdam : Elsevier, 2019-
local.accessrights.dnbfree-
Enthalten in den Sammlungen:Open Access Publikationen der MLU

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