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Title: On the influence of the rhodamine substituents onto the cytotoxicity of mitocanic maslinic acid rhodamine conjugates
Author(s): Kozubek, Marie
Denner, Toni C.
Eckert, MarcLook up in the Integrated Authority File of the German National Library
Hoenke, Sophie
Csuk, RenéLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Maslinic acid was converted via a di-acetylated piperazinyl amide into rhodamine conjugates differing in their alkyl moieties. These conjugates were submitted to cytotoxicity assays employing a panel of human tumor cell lines. These conjugates held high cytotoxicity but also some selectivity especially for A2780 cells. Thereby, a propyl substituted rhodamine conjugate showed EC50 values as low as EC50 = 0.01 μM and was approx. 15 times more cytotoxic for the cancer cells than for non-malignant fibroblasts (NIH 3 T3). Cytotoxicity obviously parallels the lipophilicity of the residue and suggests - since the compounds act as mitocanes - an interaction of the conjugates with the inner mitochondrial membrane.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Results in chemistry
Publisher: Elsevier
Publisher Place: Amsterdam
Volume: 5
Original Publication: 10.1016/j.rechem.2022.100708
Appears in Collections:Open Access Publikationen der MLU

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