Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/101913
Title: | Towards a network control theory of electroconvulsive therapy response |
Author(s): | Hahn, Tim Redlich, Ronny |
Issue Date: | 2023 |
Type: | Article |
Language: | English |
Abstract: | Electroconvulsive Therapy (ECT) is arguably the most effective intervention for treatment-resistant depression. While large interindividual variability exists, a theory capable of explaining individual response to ECT remains elusive. To address this, we posit a quantitative, mechanistic framework of ECT response based on Network Control Theory (NCT). Then, we empirically test our approach and employ it to predict ECT treatment response. To this end, we derive a formal association between Postictal Suppression Index (PSI)—an ECT seizure quality index—and whole-brain modal and average controllability, NCT metrics based on white-matter brain network architecture, respectively. Exploiting the known association of ECT response and PSI, we then hypothesized an association between our controllability metrics and ECT response mediated by PSI. We formally tested this conjecture in N = 50 depressive patients undergoing ECT. We show that whole-brain controllability metrics based on pre-ECT structural connectome data predict ECT response in accordance with our hypotheses. In addition, we show the expected mediation effects via PSI. Importantly, our theoretically motivated metrics are at least on par with extensive machine learning models based on pre-ECT connectome data. In summary, we derived and tested a control-theoretic framework capable of predicting ECT response based on individual brain network architecture. It makes testable, quantitative predictions regarding individual therapeutic response, which are corroborated by strong empirical evidence. Our work might constitute a starting point for a comprehensive, quantitative theory of personalized ECT interventions rooted in control theory. |
URI: | https://opendata.uni-halle.de//handle/1981185920/103864 http://dx.doi.org/10.25673/101913 |
Open Access: | Open access publication |
License: | (CC BY 4.0) Creative Commons Attribution 4.0 |
Journal Title: | PNAS nexus |
Publisher: | Oxford University Press |
Publisher Place: | Oxford |
Volume: | 2 |
Issue: | 2 |
Original Publication: | 10.1093/pnasnexus/pgad032 |
Page Start: | 1 |
Page End: | 7 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
pgad032.pdf | 455.66 kB | Adobe PDF | View/Open |