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Title: Efficiency of cutaneous heat diffusion after local hyperthermia for the treatment of itch
Author(s): Wohlrab, JohannesLook up in the Integrated Authority File of the German National Library
Mentel, TimLook up in the Integrated Authority File of the German National Library
Eichner, Adina
Issue Date: 2023
Type: Article
Language: English
Abstract: Background: Today, itching is understood as an independent sensory perception, which is based on a complex etiology of a disturbed neuronal activity and leads to clinical symptoms. The primary afferents (pruriceptors) have functional overlaps with afferents of thermoregulation (thermoceptors). Thus, an antipruritic effect can be caused by antagonizing heat-sensitive receptors of the skin. The ion channel TRP-subfamily V member 1 (TRPV1) is of particular importance in this context. Repeated heat application can induce irreversible inactivation by unfolding of the protein, causing a persistent functional deficit and thus clinically and therapeutically reducing itch sensation. Material and methods: To demonstrate relevant heat diffusion after local application of heat (45°C to 52°C for 3 and 5 seconds) by a technical medical device, the temperature profile for the relevant skin layer was recorded synchronously on ex vivo human skin using an infrared microscope. Results: The results showed that the necessary activation temperature for TRPV1 of (≥43°C) in the upper relevant skin layers was safely reached after 3 and 5 seconds of application time. There were no indications of undesirable thermal effects. Conclusion: The test results show that the objectified performance of the investigated medical device can be expected to provide the necessary temperature input for the activation of heat-sensitive receptors in the skin. Clinical studies are necessary to prove therapeutic efficacy in the indication pruritus.
Open Access: Open access publication
License: (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0(CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0
Journal Title: Skin research & technology
Publisher: Wiley-Blackwell
Publisher Place: Oxford [u.a.]
Volume: 29
Issue: 2
Original Publication: 10.1111/srt.13277
Appears in Collections:Open Access Publikationen der MLU