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Title: Stem cell therapy in diabetic polyneuropathy : recent advancements and future directions
Author(s): Akter, Shamima
Choubey, Mayank
Mohib, Mohammad Mohabbulla
Arbee, Shahida
Sagor, Abu Taher
Sarif Mohiuddin, Mohammad
Issue Date: 2023
Type: Article
Language: English
Abstract: Diabetic polyneuropathy (DPN) is the most frequent, although neglected, complication of long-term diabetes. Nearly 30% of hospitalized and 20% of community-dwelling patients with diabetes suffer from DPN; the incidence rate is approximately 2% annually. To date, there has been no curable therapy for DPN. Under these circumstances, cell therapy may be a vital candidate for the treatment of DPN. The epidemiology, classification, and treatment options for DPN are disclosed in the current review. Cell-based therapies using bone marrow-derived cells, embryonic stem cells, pluripotent stem cells, endothelial progenitor cells, mesenchymal stem cells, or dental pulp stem cells are our primary concern, which may be a useful treatment option to ease or to stop the progression of DPN. The importance of cryotherapies for treating DPN has been observed in several studies. These findings may help for the future researchers to establish more focused, accurate, effective, alternative, and safe therapy to reduce DPN. Cell-based therapy might be a permanent solution in the treatment and management of diabetes-induced neuropathy.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Brain Sciences
Publisher: MDPI AG
Publisher Place: Basel
Volume: 13
Issue: 2
Original Publication: 10.3390/brainsci13020255
Appears in Collections:Open Access Publikationen der MLU

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