Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.25673/103212
Langanzeige der Metadaten
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Thomssen, Christoph | - |
dc.contributor.author | Vetter, Martina | - |
dc.contributor.author | Kantelhardt, Eva Johanna | - |
dc.contributor.author | Meisner, Christoph | - |
dc.contributor.author | Schmidt, Marcus | - |
dc.contributor.author | Martin, Pierre M. | - |
dc.contributor.author | Clatot, Florian | - |
dc.contributor.author | Augustin, Doris | - |
dc.contributor.author | Hanf, Volker | - |
dc.contributor.author | Paepke, Daniela | - |
dc.contributor.author | Meinerz, Wolfgang | - |
dc.contributor.author | Hoffmann, Gerald | - |
dc.contributor.author | Wiest, Wolfgang | - |
dc.contributor.author | Sweep, Fred C. G. J. | - |
dc.contributor.author | Schmitt, Manfred | - |
dc.contributor.author | Jänicke, Fritz | - |
dc.contributor.author | Loibl, Sibylle | - |
dc.contributor.author | Minckwitz, Gunter | - |
dc.contributor.author | Harbeck, Nadia | - |
dc.date.accessioned | 2023-05-09T12:01:47Z | - |
dc.date.available | 2023-05-09T12:01:47Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/105164 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/103212 | - |
dc.description.abstract | Background: In node-negative breast cancer (NNBC), a high risk of recurrence is determined by clinico-pathological or tumor-biological assessment. Taxanes may improve adjuvant chemotherapy. Methods: NNBC 3-Europe, the first randomized phase-3 trial in node-negative breast cancer (BC) with tumor-biological risk assessment, recruited 4146 node-negative breast cancer patients from 2002 to 2009 in 153 centers. Risk assessment was performed by clinico-pathological factors (43%) or biomarkers (uPA/PAI-1, urokinase-type plasminogen activator/its inhibitor PAI-1). High-risk patients received six courses 5-fluorouracil (500 mg/m2), epirubicin (100 mg/m2), cyclophosphamide (500 mg/m2) (FEC), or three courses FEC followed by three courses docetaxel 100 mg/m2 (FEC-Doc). Primary endpoint was disease-free survival (DFS). Results: In the intent-to-treat population, 1286 patients had received FEC-Doc, and 1255 received FEC. Median follow-up was 45 months. Tumor characteristics were equally distributed; 90.6% of tested tumors had high uPA/PAI-1-concentrations. Planned courses were given in 84.4% (FEC-Doc) and 91.5% (FEC). Five-year-DFS was 93.2% (95% C.I. 91.1–94.8) with FEC-Doc and 93.7% (91.7–95.3) with FEC. Five-year-overall survival was 97.0% (95.4–98.0) for FEC-Doc and 96.6% % (94.9–97.8) for FEC. Conclusions: With adequate adjuvant chemotherapy, even high-risk node-negative breast cancer patients have an excellent prognosis. Docetaxel did not further reduce the rate of early recurrences and led to significantly more treatment discontinuations. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 618 | - |
dc.title | Adjuvant docetaxel in node-negative breast cancer patients : a randomized trial of AGO-Breast Study Group, German Breast Group, and EORTC-Pathobiology Group | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Cancers | - |
local.bibliographicCitation.volume | 15 | - |
local.bibliographicCitation.issue | 5 | - |
local.bibliographicCitation.publishername | MDPI | - |
local.bibliographicCitation.publisherplace | Basel | - |
local.bibliographicCitation.doi | 10.3390/cancers15051580 | - |
local.subject.keywords | node-negative breast cancer; uPA/PAI-1; adjuvant chemotherapy; docetaxel | - |
local.openaccess | true | - |
dc.identifier.ppn | 1844904083 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2023-05-09T12:01:23Z | - |
local.bibliographicCitation | Enthalten in Cancers - Basel : MDPI, 2009 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
cancers-15-01580-v3.pdf | 1.44 MB | Adobe PDF | ![]() Öffnen/Anzeigen |