Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/103280
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DC Field | Value | Language |
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dc.contributor.author | Arndt, Lilli | - |
dc.contributor.author | Lindhorst, Andreas | - |
dc.contributor.author | Neugebauer, Julia | - |
dc.contributor.author | Hoffmann, Anne | - |
dc.contributor.author | Hobusch, Constance | - |
dc.contributor.author | Alexakē, Basileia-Ismēnē | - |
dc.contributor.author | Ghosh, Adhideb | - |
dc.contributor.author | Blüher, Matthias | - |
dc.contributor.author | Wolfrum, Christian | - |
dc.contributor.author | Glaß, Markus | - |
dc.contributor.author | Gericke, Martin | - |
dc.date.accessioned | 2023-05-12T12:15:50Z | - |
dc.date.available | 2023-05-12T12:15:50Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/105232 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/103280 | - |
dc.description.abstract | White adipose tissue (WAT) fibrosis, characterized by an excess of extracellular (ECM) matrix components, is strongly associated with WAT inflammation and dysfunction due to obesity. Interleukin (IL)-13 and IL-4 were recently identified as critical mediators in the pathogenesis of fibrotic diseases. However, their role in WAT fibrosis is still ill-defined. We therefore established an ex vivo WAT organotypic culture system and demonstrated an upregulation of fibrosis-related genes and an increase of α-smooth muscle actin (αSMA) and fibronectin abundance upon dose-dependent stimulation with IL-13/IL-4. These fibrotic effects were lost in WAT lacking il4ra, which encodes for the underlying receptor controlling this process. Adipose tissue macrophages were found to play a key role in mediating IL-13/IL-4 effects in WAT fibrosis as their depletion through clodronate dramatically decreased the fibrotic phenotype. IL-4-induced WAT fibrosis was partly confirmed in mice injected intraperitoneally with IL-4. Furthermore, gene correlation analyses of human WAT samples revealed a strong positive correlation of fibrosis markers with IL-13/IL-4 receptors, whereas IL13 and IL4 correlations failed to confirm this association. In conclusion, IL-13 and IL-4 can induce WAT fibrosis ex vivo and partly in vivo, but their role in human WAT remains to be further elucidated. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | The role of IL-13 and IL-4 in adipose tissue fibrosis | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | International journal of molecular sciences | - |
local.bibliographicCitation.volume | 24 | - |
local.bibliographicCitation.issue | 6 | - |
local.bibliographicCitation.pagestart | 1 | - |
local.bibliographicCitation.pageend | 19 | - |
local.bibliographicCitation.publishername | Molecular Diversity Preservation International | - |
local.bibliographicCitation.publisherplace | Basel | - |
local.bibliographicCitation.doi | 10.3390/ijms24065672 | - |
local.subject.keywords | adipose tissue; fibrosis; IL-13; IL-4; macrophages; obesity | - |
local.openaccess | true | - |
dc.identifier.ppn | 1845303814 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2023-05-12T12:15:06Z | - |
local.bibliographicCitation | Enthalten in International journal of molecular sciences - Basel : Molecular Diversity Preservation International, 2000 | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
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File | Description | Size | Format | |
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ijms-24-05672.pdf | 2.68 MB | Adobe PDF | ![]() View/Open |