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http://dx.doi.org/10.25673/108834
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DC Element | Wert | Sprache |
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dc.contributor.author | Grundmann, Sarah Maria | - |
dc.contributor.author | Schutkowski, Alexandra | - |
dc.contributor.author | Berger, Christian | - |
dc.contributor.author | Bailer, Anja Christina | - |
dc.contributor.author | König, Bettina | - |
dc.contributor.author | Stangl, Gabriele I. | - |
dc.date.accessioned | 2023-07-05T12:13:49Z | - |
dc.date.available | 2023-07-05T12:13:49Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/110789 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/108834 | - |
dc.description.abstract | The consumption of phosphorus in Western populations largely exceeds the recommended intake, while vitamin D supply is often insufficient. Both situations are linked to an increased cardiovascular risk. A 17-week two-factorial study with Ldl receptor-/- mice was conducted to investigate the cardiovascular impact of dietary phosphorus [adequate (0.3%; P0.3) vs. high (1.5%; P1.5)] in combination with a low (50 IU/kg; D50) or adequate vitamin D diet (1000 IU/kg; D1000). The data demonstrate that mice fed the P1.5 vs. P0.3 diets developed smaller vascular lesions (p = 0.013) and cardiac hypotrophy (p = 0.011), which were accompanied by diminished IGF1 and insulin signalling activity in their hearts. Vitamin D showed no independent effect on atherogenesis and heart morphology. Feeding P1.5 vs. P0.3 diets resulted in markedly reduced serum triacylglycerols (p < 0.0001) and cholesterol (p < 0.0001), higher faecal lipid excretion (p < 0.0001) and a reduced mRNA abundance of hepatic sterol exporters and lipoprotein receptors. Minor hypocholesterolaemic and hypotriglyceridaemic effects were also found in mice fed the D1000 vs. D50 diets (p = 0.048, p = 0.026). To conclude, a high phosphorus intake strongly affected the formation of vascular lesions, cardiac morphology, and lipid metabolism, although these changes are not indicative of an increased cardiovascular risk. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 572 | - |
dc.title | High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Scientific reports | - |
local.bibliographicCitation.volume | 10 | - |
local.bibliographicCitation.publishername | Macmillan Publishers Limited, part of Springer Nature | - |
local.bibliographicCitation.publisherplace | [London] | - |
local.bibliographicCitation.doi | 10.1038/s41598-020-77509-w | - |
local.openaccess | true | - |
dc.identifier.ppn | 1851818588 | - |
local.bibliographicCitation.year | 2020 | - |
cbs.sru.importDate | 2023-07-05T12:13:12Z | - |
local.bibliographicCitation | Enthalten in Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
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Datei | Beschreibung | Größe | Format | |
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s41598-020-77509-w.pdf | 1.64 MB | Adobe PDF | ![]() Öffnen/Anzeigen |