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http://dx.doi.org/10.25673/110038
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DC Element | Wert | Sprache |
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dc.contributor.author | Neroev, Vladimir | - |
dc.contributor.author | Malishevskaya, Tatyana | - |
dc.contributor.author | Weinert, Dietmar | - |
dc.contributor.author | Astakhov, Sergei | - |
dc.contributor.author | Kolomeichuk, Sergey | - |
dc.contributor.author | Cornelissen, Germaine | - |
dc.contributor.author | Kabitskaya, Yana | - |
dc.contributor.author | Boiko, Elena | - |
dc.contributor.author | Nemtsova, Irina | - |
dc.contributor.author | Gubin, Denis | - |
dc.date.accessioned | 2023-08-23T07:36:42Z | - |
dc.date.available | 2023-08-23T07:36:42Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/111993 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/110038 | - |
dc.description.abstract | Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of “marker” circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients (p < 0.0001). The 24-h IOP phase correlated with RGC loss (p < 0.0001). The internal phase shift between IOP and body temperature gradually increased with POAG progression (p < 0.001). Angiotensin converting enzyme Alu-repeat deletion/insertion (ACE I/D) emerged as a candidate gene polymorphism, which may play a role in the alteration of the circadian IOP variability in advanced glaucoma. To conclude, a reliable estimation of the 24-h rhythm in IOP requires the degree of RGC damage to be assessed. In advanced POAG, the 24-h phase of IOP tended to occur during the night and correlated with RGC loss, being progressively delayed relative to the phase of temperature. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 570 | - |
dc.title | Disruption of 24-hour rhythm in intraocular pressure correlates with retinal ganglion cell loss in glaucoma | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | International journal of molecular sciences | - |
local.bibliographicCitation.volume | 22 | - |
local.bibliographicCitation.issue | 1 | - |
local.bibliographicCitation.pagestart | 1 | - |
local.bibliographicCitation.pageend | 18 | - |
local.bibliographicCitation.publishername | Molecular Diversity Preservation International | - |
local.bibliographicCitation.publisherplace | Basel | - |
local.bibliographicCitation.doi | 10.3390/ijms22010359 | - |
local.subject.keywords | glaucoma; intraocular pressure; retinal ganglion cells; optical coherence tomography circadian; temperature; angiotensin converting enzyme gene | - |
local.openaccess | true | - |
dc.identifier.ppn | 1857659856 | - |
local.bibliographicCitation.year | 2021 | - |
cbs.sru.importDate | 2023-08-23T07:36:12Z | - |
local.bibliographicCitation | Enthalten in International journal of molecular sciences - Basel : Molecular Diversity Preservation International, 2000 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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ijms-22-00359.pdf | 2.24 MB | Adobe PDF | ![]() Öffnen/Anzeigen |